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anti-Human NR3C2 Antibodies:
anti-Rat (Rattus) NR3C2 Antibodies:
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Human Polyclonal NR3C2 Primary Antibody for WB - ABIN2777197
Caprio, Newfell, la Sala, Baur, Fabbri, Rosano, Mendelsohn, Jaffe: Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. in Circulation research 2008
Chicken Polyclonal NR3C2 Primary Antibody for IHC, WB - ABIN2773864
Liu, Grifman, Keily, Chatterton, Staal, Li: Mineralocorticoid receptor is involved in the regulation of genes responsible for hepatic glucose production. in Biochemical and biophysical research communications 2006
Data demonstrate that there are distinct differences between the human mineralocorticoid receptor (MR) and the zebrafish MR despite considerable sequence and functional conservation.
Data show that aldosterone via the mineralocorticoid receptor (MR) reduces microRNA miR (show MLXIP Antibodies)-29b in vivo in murine aorta and in human primary and cultured vascular smooth muscle cells (VSMCs).
NR3C2 was found to be significantly associated with longitudinal systolic Blood Pressure change in a Han Chinese population.
Findings indicate that CS-3150 is a selective and highly potent mineralocorticoid receptor antagonist with long-lasting oral activity.
Among the class II HDACs, HDAC4 (show HDAC4 Antibodies) interacted with both MR and HDAC3 (show HDAC3 Antibodies) after aldosterone stimulation. The nuclear translocation of HDAC4 (show HDAC4 Antibodies) was mediated by protein kinase A (PKA) and protein phosphatases (PP)
CBP (show CREBBP Antibodies) and p300 (show EP300 Antibodies) as lysine acetyltransferases responsible for the regulation of MR
Data indicate that finerenone inhibits mineralocorticoid receptor (MR), steroid receptor coactivator-1 (show NCOA1 Antibodies) binding at the regulatory sequence.
MR expression was decreased in PTSD patients with low HPA (show HPSE Antibodies) axis reactivity compared to PTSD patients with high HPA (show HPSE Antibodies) axis reactivity.
These findings indicate that GEMIN4 (show GEMIN4 Antibodies) functions as a novel coregulator of the MR.
Data suggest that NR3C2 activation plays role in pathogenesis of cardiovascular diseases; targeted drug therapy with NR3C2 antagonists may prevent progression of cardiovascular diseases to acute situations such as sudden cardiac arrest. [REVIEW]
Vascular mineralocorticoid receptor and blood pressure regulation
Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin (show REN Antibodies)-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload
Data indicate that endothelial cell mineralocorticoid receptor (MR) deficiency prevented Western diet (WD)-induced diastolic dysfunction, profibrotic, and progrowth signaling.
Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult.
a cooperative role of MR and cav-1 (show CAV1 Antibodies) in regulating vascular contraction and NO-cGMP-mediated relaxation during low NO-high AngII-dependent cardiovascular injury
Upregulation of MR in mouse adipocytes led to increased weight and fat mass, insulin (show INS Antibodies) resistance, and metabolic syndrome features without affecting blood pressure.
Data showed that the mRNA expression of glucocorticoid and mineralocorticoid receptors were significantly decreased in splenic macrophages by repeated social defeat. Epigenetic regulation, may play a role in the RSD-induced GC resistance.
Compared to sham-mice, the expression levels of hypothalamic MR, serum glucocorticoid-induced kinase 1 (a marker of MR activity) and AT1R (show AGTRAP Antibodies) increased in pressure-overload-mice.
Data indicate that overexpression of constitutively active Rac1 activated mineralocorticoid receptor (MR).
AT1 (show SLC33A1 Antibodies)-independent MR activation in the LV might be responsible for the pathogenesis of diabetic cardiomyopathy.
MR antagonists up-regulated brown-adipocyte-specific transcripts and protein levels of uncoupling protein 1 (show UCP1 Antibodies) in visceral and inguinal fat compared with the high fat diet group. Adipocyte MR regulates brown remodeling of white fat by modulating autophagy.
Effects of age, weaning and/or social isolation on the expression of genes regulating mineralocorticoid receptor.
analysis of the interdomain interaction in the mineralocorticoid receptor
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
, nuclear receptor subfamily 3, group C, member 2
, nuclear receptor subfamily 3 group C member 2
, aldosterone receptor
, mineralocorticoid receptor 1
, mineralocorticoid receptor delta
, Mineralocorticoid receptor (aldosterone receptor)