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Caspase 4 antibody
CASP4
Reactivity: Human, Monkey
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Caspase 4 Antibody
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Target
See all Caspase 4 (CASP4) Antibodies
Caspase 4 (CASP4)
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
Reactivity
All reactivities for Caspase 4 antibodies
Human, Monkey
Host
All hosts for Caspase 4 antibodies
Rabbit
Clonality
All clonalities for Caspase 4 antibodies
Polyclonal
Conjugate
All conjugates for Caspase 4 antibodies
This Caspase 4 antibody is un-conjugated
Application
All applications for Caspase 4 antibodies
Western Blotting (WB)
Specificity
The affinity purified antibody detects the 43 kDa proform of caspase-4.
Purification
Immunoaffinity purified
Immunogen
Synthetic peptide surrounding amino acid 100 of human caspase-4
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Alternatives
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Application Details
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Application Notes
Western Blot: 0,5-4g/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
0.2 mg/mL
Buffer
PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative
Thimerosal (Merthiolate)
Precaution of Use
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C/-80 °C
Storage Comment
Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
Target Details for Caspase 4
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Target
Caspase 4 (CASP4)
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
Alternative Name
Caspase-4 (CASP4 Products )
Synonyms
ICE(rel)II antibody, ICEREL-II antibody, ICH-2 antibody, Mih1/TX antibody, TX antibody, Casp11 antibody, CASP13 antibody, CASP1 antibody, CASP4 antibody, Caspl antibody, ich-3 antibody, Casp4 antibody, caspase 4 antibody, caspase 4, apoptosis-related cysteine peptidase antibody, caspase-4 antibody, CASP4 antibody, Casp4 antibody, LOC100731032 antibody
Background
Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-4 is also known as Ich-2, TX, and ICErel-II and can proteolytically processed by granzyme B. Over expression of caspase-4 induces apoptosis in Rat-1 and HeLa cells, which can be inhibited by CrmA and Bcl-2.Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
Gene ID
837
NCBI Accession
NP_001216
UniProt
P49662
Pathways
Apoptosis , Caspase Cascade in Apoptosis , Positive Regulation of Endopeptidase Activity
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