TNFRSF10B antibody
TNFRSF10B
Reactivity: Human
FACS, ELISA, IP, Func
Host: Mouse
Monoclonal
B-D37
unconjugated
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Target
See all TNFRSF10B Antibodies
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TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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Reactivity
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Human
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Host
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Mouse
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Clonality
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Monoclonal
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Conjugate
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This TNFRSF10B antibody is un-conjugated
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Application
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Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Functional Studies (Func)
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Specificity
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Recognises a 42-46 kDa protein
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Purification
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Ion exchange chromatography
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Sterility
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0.22 μm filtered
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Immunogen
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Recombinant human TRAIL R2/Fc chimera,Myeloma X63/AG.8653 x Balb/c spleen cells
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Clone
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B-D37
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Isotype
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IgG2b, kappa
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Biological Activity Comment
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Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line
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Top Product
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Discover our top product TNFRSF10B Primary Antibody
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Application Notes
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Optimal working dilution should be determined by the investigator.
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Restrictions
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For Research Use only
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Format
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Liquid
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Buffer
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Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
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Preservative
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Without preservative
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Storage
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4 °C
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Storage Comment
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Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
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Mérino, Lalaoui, Morizot, Schneider, Solary, Micheau: "Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7046-55, (2006) (PubMed).
Vermot-Desroches, Sergent, Bonnin, Wijdenes: "Characterization of monoclonal antibodies directed against trail or trail receptors." in: Cellular immunology, Vol. 236, Issue 1-2, pp. 86-91, (2005) (PubMed).
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Target
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TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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Alternative Name
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TRAIL R2 (TNFRSF10B Products)
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Synonyms
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TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
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Background
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DR5, TRAIL R2
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Molecular Weight
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42-46 kDa
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Pathways
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p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity
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