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TNFRSF10B antibody (AA 388-407)
TNFRSF10B
Reactivity: Human, Mouse
WB, ICC, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TNFRSF10B Antibody
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Target
See all TNFRSF10B Antibodies
TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Binding Specificity
All epitopes for TNFRSF10B antibodies
AA 388-407
Reactivity
All reactivities for TNFRSF10B antibodies
Human, Mouse
Host
All hosts for TNFRSF10B antibodies
Rabbit
Clonality
All clonalities for TNFRSF10B antibodies
Polyclonal
Conjugate
All conjugates for TNFRSF10B antibodies
This TNFRSF10B antibody is un-conjugated
Application
All applications for TNFRSF10B antibodies
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificity
Reacts with human and mouse DR5.
Purification
Purified
Immunogen
Synthetic peptide corresponding to aa 388- 407 of human DR5 precursor (accession no.AF012535)
Isotype
IgG
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Discover our top product TNFRSF10B Primary Antibody
Alternatives
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Application Details
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Application Notes
Working dilution: Optimal dilution should be determined by the end user. The following are guidelines only: WB(2 μg/mL) ICC(5 μg/mL)
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS, pH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Dilute in PBS or medium which is identical to that used in the assay system.
Storage
-20 °C
Storage Comment
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Target Details for TNFRSF10B
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Target
TNFRSF10B
(Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
Alternative Name
DR5 (TNFRSF10B Products )
Synonyms
TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family. A novel death domain containing receptor for TRAIL was recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several independent laboratories. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Tumor necrosis factor receptor superfamily member 10B Death receptor 5 TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2 CD_antigen: CD262 KILLER/DR5,TRICK2A, TRICK2B, TRICKB Gene name: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Gene ID
8795
UniProt
O14763
Pathways
p53 Signaling , Apoptosis , Positive Regulation of Endopeptidase Activity
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