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STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 725-729)

Details for Product anti-STAT3 Antibody No. ABIN197177, Supplier: Log in to see
Antigen
  • 1110034C02Rik
  • APRF
  • Aprf
  • aprf
  • AW109958
  • hies
  • HIES
  • stat3
  • wu:fc15d02
  • wu:fl59g06
  • Xstat3
  • z-Stat3
Alternatives
anti-Human STAT3 antibody for Western Blotting
Epitope
AA 725-729
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This STAT3 antibody is un-conjugated
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Supplier
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Immunogen Syntehtic peptide KLH conjugated corresponding to sequence around amino acids 725~729 (P-M-SP-P-R) derived from Human STAT3 protein.
Specificity This antibody detects endogenous levels of total STAT3 protein.
Purification Affinity-Chromatography using epitope-specific peptide
Alternative Name STAT3 (STAT3 Antibody Abstract)
Background STAT3 is a key signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development. STAT3 is also constitutively activated in a number of human tumors, possesses oncogenic potential, and anti-apoptotic activities. Following phosphorylation at Y705, STAT3 dimerizes, translocates to the nucleus and binds DNA. Transcriptional activation seems to be regulated by phosphorylation at Ser 727. STAT3 exists as an alpha form (86kD) and a beta form (79kD) that lacks a 50 amino acid domain containing Ser 727.Synonyms: APRF, Acute-phase response factor, STAT-3, Signal transducer and activator of transcription 3
Gene ID 6774
NCBI Accession NP_003141
UniProt P40763
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors, Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway
Application Notes Western Blot: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50approx. 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 725-729) (ABIN197177) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 725-729) antibody
 image for anti-STAT3 antibody (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)) (AA 725-729) (ABIN197177) anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (AA 725-729) antibody (Image 2)
Background publications Heim: "The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus." in: Journal of receptor and signal transduction research, Vol. 19, Issue 1-4, pp. 75-120, 1999 (PubMed).

Catlett-Falcone, Landowski, Oshiro, Turkson, Levitzki, Savino, Ciliberto, Moscinski, Fernández-Luna, Nuñez, Dalton, Jove: "Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells." in: Immunity, Vol. 10, Issue 1, pp. 105-15, 1999 (PubMed).

Bromberg, Wrzeszczynska, Devgan, Zhao, Pestell, Albanese, Darnell: "Stat3 as an oncogene." in: Cell, Vol. 98, Issue 3, pp. 295-303, 1999 (PubMed).

Garcia, Jove: "Activation of STAT transcription factors in oncogenic tyrosine kinase signaling." in: Journal of biomedical science, Vol. 5, Issue 2, pp. 79-85, 1998 (PubMed).

Takeda, Noguchi, Shi, Tanaka, Matsumoto, Yoshida, Kishimoto, Akira: "Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3801-4, 1997 (PubMed).