HIF1A antibody (AA 579-826)

Catalog No. ABIN1992685

Product Details anti-HIF1A Antibody

Target: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Binding Specificity: AA 579-826

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIF1A antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Hypoxia-inducible factor 1-alpha protein (579-826AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HIF1A

Target: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Alternative Name: HIF1A (HIF1A Products)

Synonyms: hif1a antibody, AA959795 antibody, HIF1alpha antibody, MOP1 antibody, bHLHe78 antibody, HIF-1A antibody, HIF-1alpha antibody, HIF1 antibody, HIF1-ALPHA antibody, PASD8 antibody, HIF1-alpha antibody, hif-1a antibody, hypoxia inducible factor 1 alpha antibody, hypoxia inducible factor 1, alpha subunit antibody, hypoxia inducible factor 1 alpha subunit antibody, HIF (Hypoxia Inducible Factor) homologa antibody, hif-1a antibody, Hif1a antibody, HIF1A antibody, hif1a antibody, hif-1 antibody

Background:

Background: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5\\\'-[AG]CGTG-3\\\' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Aliases: ARNT interacting protein antibody, ARNT-interacting protein antibody, Basic helix loop helix PAS protein MOP1 antibody, Basic-helix-loop-helix-PAS protein MOP1 antibody, bHLHe78 antibody, Class E basic helix-loop-helix protein 78 antibody, HIF 1A antibody, HIF 1alpha antibody, HIF-1-alpha antibody, HIF-1alpha antibody, HIF-alpha antibody, HIF1 A antibody, HIF1 Alpha antibody, HIF1 antibody, HIF1-alpha antibody, HIF1A antibody, HIF1A_HUMAN antibody, hifla antibody, Hypoxia inducible factor 1 alpha antibody, Hypoxia inducible factor 1 alpha isoform I.3 antibody, Hypoxia inducible factor 1 alpha subunit antibody, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor antibody, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor) antibody, Hypoxia inducible factor1alpha antibody, Hypoxia-inducible factor 1-alpha antibody, Member of PAS protein 1 antibody, Member of PAS superfamily 1 antibody, Member of the PAS Superfamily 1 antibody, MOP 1 antibody, MOP1 antibody, PAS domain-containing protein 8 antibody, PASD 8 antibody, PASD8 antibody

UniProt: Q16665

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, Warburg Effect