Integrin beta 2 antibody (AA 534-546)

Catalog No. ABIN2469881

Product Details anti-Integrin beta 2 Antibody

Target: Integrin beta 2 (ITGB2)

Binding Specificity: AA 534-546

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Specificity: Recongizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit, beta2 integrin).

Purification: Protein A Column

Immunogen: Integrin beta 2 monoclonal antibody was raised against Integrin beta 2 (Human).

Clone: MEM-48

Isotype: IgG1

Application Details

Application Notes: Integrin beta 2 antibody can be used in ELISA starting at 1:100000, Western Blot starting at 1:1000 - 1:10000, and immunohistochemistry starting at 5 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 15 mM sodium azide, approx., pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Integrin beta 2 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: Integrin beta 2 (ITGB2 Products)

Synonyms: CD18 antibody, LAD antibody, LCAMB antibody, LFA-1 antibody, MAC-1 antibody, MF17 antibody, MFI7 antibody, 2E6 antibody, AI528527 antibody, Cd18 antibody, Lfa1 antibody, ITGB2 antibody, itgb2 antibody, itgb2-a antibody, itgb2-b antibody, integrin subunit beta 2 antibody, integrin beta 2 antibody, integrin subunit beta 2 S homeolog antibody, ITGB2 antibody, Itgb2 antibody, itgb2.S antibody

Background: CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes. The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Gene ID: 3689

UniProt: P05107

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation