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IL12 antibody
IL12
Reactivity: Human
FACS
Host: Mouse
Monoclonal
7B12
unconjugated
Product Details anti-IL12 Antibody
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Target
See all IL12 Antibodies
IL12
(Interleukin 12 (IL12))
Reactivity
All reactivities for IL12 antibodies
Human
Host
All hosts for IL12 antibodies
Mouse
Clonality
All clonalities for IL12 antibodies
Monoclonal
Conjugate
All conjugates for IL12 antibodies
This IL12 antibody is un-conjugated
Application
All applications for IL12 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
7B12
Isotype
IgG1
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Discover our top product IL12 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for IL12
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Target
IL12
(Interleukin 12 (IL12))
Alternative Name
IL-12 (IL12 Products )
Synonyms
CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, LOC100217488 antibody, IL-12p35 antibody, Il-12a antibody, Ll12a antibody, p35 antibody, IL12p40 antibody, IL12B antibody, IL-12 p35 antibody, interleukin 12B antibody, interleukin 12A antibody, interleukin 12b antibody, interleukin 12a antibody, Interleukin 12 level antibody, IL12B antibody, IL12A antibody, Il12b antibody, Il12a antibody, IL12 antibody, il12a antibody
Background
Bioactive IL-12 is a potent regulator of cell-mediated immune responses and key mediator of Th1 cell development. Bioactive IL-12 is secreted by activated B lymphocytes, dendritic cells and macrophages as a 70 kD heterodimeric glycoprotein comprised of disulfide-bonded 35 kD and 40 kD subunits. The disulfide-linked p40 homodimer can bind to IL-12 receptors and antagonize the activities of bioactive IL-12. The 7B12 antibody reacts with human IL-12 p70 heterodimer, but shows no reactivity with IL-12 p35 or p40 monomer. The 7B12 has high affinity to human IL-12 p70 heterodimer.
Pathways
JAK-STAT Signaling , TLR Signaling , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Activated T Cell Proliferation , Cancer Immune Checkpoints , Inflammasome
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