AIM2 antibody (AA 1-186)

Catalog No. ABIN2666309

Product Details anti-AIM2 Antibody

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Binding Specificity: AA 1-186

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AIM2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Immunogen: AA 1-186 of human AIM2 with GST tag.

Clone: 3B10

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.

Storage: 4 °C

Storage Comment: Upon receipt, store undiluted between 2°C and 8°C.

Target Details for AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Alternative Name: AIM2 (AIM2 Products)

Synonyms: AIM2 antibody, PYHIN4 antibody, Gm1313 antibody, Ifi210 antibody, absent in melanoma 2 antibody, AIM2 antibody, Aim2 antibody

Background: AIM2 is one of the human IFN-inducible proteins, encoding a 39 kD protein. It contains a 200 amino acid repeat, which is a signature of the HIN-200 family (hematopoietic IFN-inducible nuclear proteins). Expression of AIM2 can inhibit cell growth and tumor formation, possibly through inducing apoptosis and suppressing nuclear factor-kappa B transcriptional activity and desensitizing tumor necrosis factor-alpha-mediated nuclear factor-kappa B activation. Furthermore, the gene for AIM2 shows a high frequency of mutations associated with microsatellite unstable colorectal cancers. AIM2 plays a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18. AIM2 is also essential for mediating inflammatory reactions triggered by cytoplasmic DNA. AIM2 is an important sensor for different pathogens through the binding of cytoplasmic double-stranded DNA through HIN-200 domain and formation of inflammatsomes including ASC/AIM2. This complex then triggers caspase-1 activation. Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform.

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome