ICBP90 antibody, Np95 antibody, RNF106 antibody, hNP95 antibody, hUHRF1 antibody, AL022808 antibody, NP95 antibody, fb97f09 antibody, wu:fb97f09 antibody, zgc:63539 antibody, UHRF1 antibody, ubiquitin like with PHD and ring finger domains 1 antibody, ubiquitin-like, containing PHD and RING finger domains, 1 antibody, ubiquitin-like with PHD and ring finger domains 1 antibody, UHRF1 antibody, Uhrf1 antibody, uhrf1 antibody
Background
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. Protein Interaction Partner: UBC, H3F3B, H3F3A, HIST2H3D, HIST2H3A, HIST2H3C, UHRF1, HIST1H3F, HIST1H3B, HIST1H3E, HIST1H3C, HIST1H3D, HIST1H3A, HIST3H3, DNMT1, PARP1, PARP2, RNF2, USP7, KAT5, MPG, BTRC, CUL1, ZPR1, RB1, PRKACA, PML, SUV39H1, EZH2, SUZ12, UHRF2, USP11, HDAC1, ELAVL1, Protein Size: 793