JAK3 antibody (Tyrosine-Protein Kinase JAK3) (Middle Region)

Details for Product anti-JAK3 Antibody No. ABIN2785645, Supplier: Log in to see
Antigen
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • fae
  • wil
  • RATJAK3
  • JAK
  • Janus kinase 3
  • JAK3
  • Jak3
Alternatives
anti-Human JAK3 antibody for Immunohistochemistry
Epitope
Middle Region
17
17
15
15
11
8
7
7
5
3
3
3
2
2
2
2
2
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
102
64
45
2
1
1
1
1
1
Host
Rabbit
72
33
1
Clonality
Polyclonal
Conjugate
This JAK3 antibody is un-conjugated
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
59
44
27
19
19
14
9
7
6
4
1
1
1
1
Options
Supplier
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human JAK3
Blocking Peptide Blocking peptide for this product available: ABIN978683
Sequence KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW SFGVVLYELF
Predicted Reactivity Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against JAK3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name JAK3 (JAK3 Antibody Abstract)
Background JAK3 is a member of the Janus kinase (JAK) family of tyrosine kinases, which is involved in cytokine receptor-mediated intracellular signal transduction. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in JAK3 are associated with autosomal SCID (severe combined immunodeficiency disease).The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Protein Interaction Partner: Socs5, KIT, IL7R, TYK2, STAT6, STAT3, JAK2, JAK1, IL4R, GTF2B, ERBB3, CDK1, CD81, APOA1, UBC, SOCS3, UHRF2, STAT5A, IKBKG, ALK, SH2B2, TIAF1, INPP5D, PTPN2, STAM2, PRMT5, SOCS1, KHDRBS1, STAM, PTK2B, IRS2, SHB, JAK3, IL2RG, VIL1, FES, CD247, PTPN6, PIK3R1
Protein Size: 1124
Molecular Weight 125 kDa
Gene ID 3718
NCBI Accession NM_000215, NP_000206
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus, Activated T Cell Proliferation, Unfolded protein response
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1124 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Tyrosine-Protein Kinase JAK3 (JAK3) (Middle Region) antibody (ABIN2785645) WB Suggested Anti-JAK3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Cheng, Ross, Frost, Kirken: "Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2271-82, 2008 (PubMed).

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