CD22 antibody (C-Term)
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- Target See all CD22 Antibodies
- CD22 (CD22 Molecule (CD22))
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Binding Specificity
- C-Term
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Reactivity
- Human, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CD22 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- YSALHKRQVG DYENVIPDFP EDEGIHYSEL IQFGVGERPQ AQENVDYVIL
- Predicted Reactivity
- Horse: 79%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against CD22. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human CD22
- Top Product
- Discover our top product CD22 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 847 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CD22 (CD22 Molecule (CD22))
- Alternative Name
- CD22 (CD22 Products)
- Synonyms
- A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
- Background
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CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: UBC, CD19, INPP5D, LCP2, AP2M1, SHC1, SYK, PTPN6, PLCG1, PIK3R1, LYN, PTPRC, IGHM, HP, ST6GAL1, ATP2B4, GRB2, AP2A1,
Protein Size: 847 - Molecular Weight
- 95 kDa
- Gene ID
- 933
- NCBI Accession
- NM_001771, NP_001762
- UniProt
- P20273
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