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EIF2AK2 antibody (AA 449-453)
EIF2AK2
Reactivity: Human
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-EIF2AK2 Antibody
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Target
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EIF2AK2
(Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
Binding Specificity
All epitopes for EIF2AK2 antibodies
AA 449-453
Reactivity
All reactivities for EIF2AK2 antibodies
Human
Host
All hosts for EIF2AK2 antibodies
Rabbit
Clonality
All clonalities for EIF2AK2 antibodies
Polyclonal
Conjugate
All conjugates for EIF2AK2 antibodies
This EIF2AK2 antibody is un-conjugated
Application
All applications for EIF2AK2 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Specificity
The antibody detects endogenous level of total PKR protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Immunogen
Peptide sequence around AA 449-453 (K-G-T-L-R) derived from Human PKR. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1:50-1:100 Immunofluorescence: 1:100-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target Details for EIF2AK2
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Target
EIF2AK2
(Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
Alternative Name
PKR (EIF2AK2 Products )
Synonyms
PKR antibody, pkr antibody, EIF2AK2 antibody, DKFZp469K1934 antibody, EIF2AK1 antibody, PRKR antibody, 2310047A08Rik antibody, 4732414G15Rik antibody, AI467567 antibody, AI747578 antibody, Pkr antibody, Prkr antibody, Tik antibody, eukaryotic translation initiation factor 2 alpha kinase 2 antibody, eukaryotic translation initiation factor 2-alpha kinase 2 antibody, EIF2AK2 antibody, eif2ak2 antibody, Eif2ak2 antibody
Background
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Molecular Weight
68 kDa
NCBI Accession
NP_001129
UniProt
P19525
Pathways
DNA Damage Repair , ER-Nucleus Signaling , Hepatitis C
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