Granzyme B (GZMB) (AA 2-32), (N-Term) antibody

Details for Product No. ABIN390495, Supplier: Log in to see
Antigen
Epitope
AA 2-32, N-Term
33
23
16
14
12
12
12
12
6
5
3
3
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
276
66
46
17
16
6
5
1
Host
Rabbit
141
138
5
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
19
13
7
6
5
5
5
5
4
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
156
91
84
82
62
43
42
35
25
10
7
4
4
3
3
2
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 AA from the N-terminal region of human GZMB.
Clone RB19352
Isotype Ig
Specificity This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10~39 amino acids from the N-terminal region of human GZMB.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GZMB (GZMB Antibody Abstract)
Background Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Synonyms: Granzyme B, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11, GRB, CTLA1, CSPB, CGL1, GZMB
Molecular Weight 27688 DA
Gene ID 3002
UniProt P10144
Research Area Apoptosis/Necrosis
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Granzyme B (GZMB) (AA 2-32), (N-Term) antibody (ABIN390495) Western blot analysis of GZMB antibody (N-term) (ABIN390495) in mouse stomach lysates...
Immunohistochemistry (IHC) image for anti-Granzyme B (GZMB) (AA 2-32), (N-Term) antibody (ABIN390495) GZMB Antibody (N-term) (ABIN390495) IHC analysis in formalin fixed and paraffin embed...
Flow Cytometry (FACS) image for anti-Granzyme B (GZMB) (AA 2-32), (N-Term) antibody (ABIN390495) GZMB Antibody (N-term) (ABIN390495) flow cytometric analysis of HL-60 cells (right hi...
Background publications Hagn, Schwesinger, Ebel, Sontheimer, Maier, Beyer, Syrovets, Laumonnier, Fabricius, Simmet, Jahrsdörfer: "Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 3, pp. 1838-45, 2009 (PubMed).

Gaafar, Aljurf, Al-Sulaiman, Iqniebi, Manogaran, Mohamed, Al-Sayed, Alzahrani, Alsharif, Mohareb, Ajarim, Tabakhi, Al-Hussein: "Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients." in: Experimental hematology, Vol. 37, Issue 7, pp. 838-48, 2009 (PubMed).

Girnita, Webber, Brooks, Ferrell, Girnita, Burckart, Chinnock, Canter, Addonizio, Bernstein, Kirklin, Naftel, Zeevi: "Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms." in: Transplantation, Vol. 87, Issue 12, pp. 1801-6, 2009 (PubMed).

Did you look for something else?