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FAK antibody (PTK2 Protein tyrosine Kinase 2) (C-Term)

Details for Product anti-PTK2 Antibody No. ABIN453801, Supplier: Login to see
Antigen
  • FADK
  • FAK
  • FAK1
  • FRNK
  • PPP1R71
  • p125FAK
  • pp125FAK
  • Fadk
  • mKIAA4203
Epitope
C-Term
69
61
58
50
46
31
22
22
20
15
14
14
13
13
13
13
11
9
9
8
7
7
7
7
6
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
638
358
331
21
6
5
3
3
2
2
2
1
1
1
Host
Rabbit
579
92
2
2
1
Clonality
Polyclonal
Conjugate
This FAK antibody is un-conjugated
18
17
16
13
12
12
11
11
11
11
11
11
3
2
2
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
467
182
155
124
103
84
54
24
15
6
6
5
4
3
2
1
Supplier
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Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human PTK2
Specificity This antibody reacts to PTK2.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name FAK1 / PTK2 (PTK2 Antibody Abstract)
Background PTK2 is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.Synonyms: FADK1, FAK, Focal adhesion kinase 1, Protein-tyrosine kinase 2, pp125FAK
Gene ID 5747
NCBI Accession NP_005598
UniProt Q05397
Pathways
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-FAK antibody (PTK2 Protein tyrosine Kinase 2) (C-Term) (ABIN453801) Western blot analysis of PTK2 (arrow) using rabbit polyclonal PTK2 Antibody (C-term) ...
Background publications Gervais, Thornberry, Ruffolo et al.: "Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 17102-8, 1998 (PubMed).

Calalb, Polte, Hanks: "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases." in: Molecular and cellular biology, Vol. 15, Issue 2, pp. 954-63, 1995 (PubMed).

Polte, Hanks: "Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 23, pp. 10678-82, 1995 (PubMed).