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- Target See all CD22 Antibodies
- CD22 (CD22 Molecule (CD22))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD22 antibody is un-conjugated
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Application
- Flow Cytometry (FACS)
- Specificity
- The antibody IS7 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes, it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- human cell line Reh
- Clone
- IS7
- Isotype
- IgG1
- Top Product
- Discover our top product CD22 Primary Antibody
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anti-CD22 Molecule (CD22) (AA 621-725) antibody
CD22 Reactivity: Human FACS, WB, ELISA, IHC, ICC Host: Mouse Monoclonal 2H1C4 unconjugated
anti-CD22 Molecule (CD22) (AA 621-725) antibodyCD22 Reactivity: Human FACS, WB, ELISA, ICC Host: Mouse Monoclonal 1A3A11 unconjugated
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 Reactivity: Human FACS, WB, ELISA, IHC, IF, Coat, StM Host: Mouse Monoclonal BLCAM-1795 unconjugated
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 Reactivity: Human FACS, WB, ELISA, IHC, IF, Coat Host: Mouse Monoclonal BLCAM-1796 unconjugated
anti-CD22 Molecule (CD22) antibodyCD22 Reactivity: Human, Non-Human Primate FACS, WB, IP Host: Mouse Monoclonal MEM-01 unconjugated
anti-CD22 Molecule (CD22) antibody (PE)CD22 Reactivity: Human, Non-Human Primate FACS Host: Mouse Monoclonal MEM-01 PE
anti-CD22 Molecule (CD22) antibody (FITC)CD22 Reactivity: Human FACS Host: Mouse Monoclonal IS7 FITC
anti-CD22 Molecule (CD22) antibodyCD22 Reactivity: Human, Mouse, Rat, Monkey, Dog WB, IHC, IHC (p) Host: Mouse Monoclonal 4C3 unconjugated
anti-CD22 Molecule (CD22) (AA 708-847) antibodyCD22 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-CD22 Molecule (CD22) (AA 52-178) antibodyCD22 Reactivity: Human IHC Host: Rabbit Monoclonal MSVA-022R unconjugated Recombinant Antibody
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- Application Notes
- Flow cytometry: Recommended dilution: 1-4 μg/mL, Positive control: lysed whole blood, lyse-wash protocol
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4
- Preservative
- Azide free
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- CD22 (CD22 Molecule (CD22))
- Alternative Name
- CD22 (CD22 Products)
- Synonyms
- A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody
- Background
- CD22 Molecule,CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.,SIGLEC2, SIGLEC-2
- Gene ID
- 933
- UniProt
- P20273
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