MICA antibody (C-Term)
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- Target See all MICA Antibodies
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MICA antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects MICA.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse
- Purification
- Peptide affinity chromatography
- Immunogen
- MICA antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MICA.
- Isotype
- IgG
- Top Product
- Discover our top product MICA Primary Antibody
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- Application Notes
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ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- Alternative Name
- MICA (MICA Products)
- Synonyms
- MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
- Background
- Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.Synonyms: MHC class I polypeptide-related sequence A, MIC-A, PERB11.1
- Gene ID
- 4276
- NCBI Accession
- NP_000238
- UniProt
- Q29983
- Pathways
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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