AIM2 antibody (Absent in Melanoma 2) (AA 4-32)

Details for Product anti-AIM2 Antibody No. ABIN653833, Supplier: Log in to see
Antigen
  • AIM2
  • PYHIN4
  • Gm1313
  • Ifi210
  • absent in melanoma 2
  • AIM2
  • Aim2
Alternatives
anti-Human AIM2 antibody for ELISA
Epitope
AA 4-32, N-Term
16
16
13
12
10
9
7
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
190
29
24
3
3
1
Host
Rabbit
90
63
40
Clonality (Clone)
Polyclonal ()
Conjugate
This AIM2 antibody is un-conjugated
9
8
8
8
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
161
84
38
22
22
14
13
13
7
2
2
2
1
Options
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Immunogen This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 AA from the N-terminal region of human AIM2.
Clone RB23659
Isotype Ig
Specificity This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AIM2 (AIM2 Antibody Abstract)
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2,AIM2
Molecular Weight 38954 DA
Gene ID 9447
UniProt O14862
Research Area Cancer, Cell Structure
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity
Application Notes WB = 1:1000, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.47 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AIM2 antibody (Absent in Melanoma 2) (AA 4-32) (ABIN653833) Western blot analysis of AIM2 Antibody (N-term) (ABIN653833) in MCF-7, HL-60, K562, H...
Flow Cytometry (FACS) image for anti-AIM2 antibody (Absent in Melanoma 2) (AA 4-32) (ABIN653833) AIM2 Antibody (N-term) (ABIN653833) flow cytometric analysis of MCF-7 cells (bottom h...
Background publications Patsos, Germann, Gebert, Dihlmann: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Hornung, Ablasser, Charrel-Dennis, Bauernfeind, Horvath, Caffrey, Latz, Fitzgerald: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Woerner, Kloor, Schwitalle, Youmans, Doeberitz, Gebert, Dihlmann: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).