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Absent in Melanoma 2 (AIM2) (N-Term), (AA 4-32) antibody

Details for Product No. ABIN653833
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Antigen
Epitope
N-Term, AA 4-32
(10), (9), (8), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (14), (13), (1)
Host
Rabbit
(52), (10), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)
(58), (34), (10), (10), (8), (7), (6), (4), (3), (2)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN653833
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Immunogen This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 AA from the N-terminal region of human AIM2.
Clone RB23659
Isotype Ig
Specificity This AIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11~40 amino acids from the N-terminal region of human AIM2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AIM2
Background AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Synonyms: Absent in melanoma 2, Interferon-inducible protein AIM2,AIM2
Molecular Weight 38954 DA
Gene ID 9447
UniProt O14862
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.47 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Absent in Melanoma 2 (AIM2) (N-Term), (AA 4-32) antibody Western blot analysis of AIM2 Antibody (N-term) (ABIN653833) in MCF-7, HL-60, K562, Hela cell line lysates (35 µg/lane). AIM2 (arrow) was detected using the purified polyclonal antibody.
anti-Absent in Melanoma 2 (AIM2) (N-Term), (AA 4-32) antibody (2) AIM2 Antibody (N-term) (ABIN653833) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Cresswell, Clarke, Jackson et al.: "Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2." in: Biochemical and biophysical research communications, Vol. 326, Issue 2, pp. 417-24, 2004 (PubMed).

Woerner, Kloor, Schwitalle et al.: "The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers." in: Genes, chromosomes & cancer, Vol. 46, Issue 12, pp. 1080-9, 2007 (PubMed).

Hornung, Ablasser, Charrel-Dennis et al.: "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC." in: Nature, Vol. 458, Issue 7237, pp. 514-8, 2009 (PubMed).

Patsos, Germann, Gebert et al.: "Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 8, pp. 1838-49, 2010 (PubMed).

Validation Images
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