Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody

Antigen: Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A)

Synonyms: HIF1, MOP1, PASD8, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF1A, HIF-1a, HIF1a, hif-1a, hif1a

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659179

Additional Information

Alternative name: HIF1A

Isotype: IgM, kappa chain

Description: Other names: HIF1A,Hypoxia-inducible factor 1-alpha,BHLHE78, MOP1, PASD8

Characteristics: Mouse Monoclonal Antibody (Mab)

Specificity: This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.

Comments:

Background: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.

Application Details

Concentration: Crude ascites

Research Area: Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Corzo, Condamine, Lu et al.: "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment." in: The Journal of experimental medicine, Vol. 207, Issue 11, pp. 2439-53, 2010 (PubMed).

Shen, Zhang, Liu et al.: "Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia." in: FEBS letters, Vol. 584, Issue 20, pp. 4366-72, 2010 (PubMed).

Hindryckx, De Vos, Jacques et al.: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, 2010 (PubMed).

Gonsalves, Kalra: "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6253-64, 2010 (PubMed).

Espinosa, José Carnicer, Catasus et al.: "Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role." in: The American journal of surgical pathology, Vol. 34, Issue 11, pp. 1708-14, 2010 (PubMed).