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Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody

Details for Product No. ABIN659179, Supplier: Log in to see
Antigen
  • hif1a
  • AA959795
  • HIF1alpha
  • MOP1
  • bHLHe78
  • HIF-1A
  • HIF-1alpha
  • HIF1
  • HIF1-ALPHA
  • PASD8
  • HIF1-alpha
  • hif-1a
Reactivity
Human
299
118
88
39
21
9
8
7
5
3
3
1
1
1
1
1
1
1
1
1
1
Host
Mouse
228
142
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
27
19
9
7
5
5
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
247
162
106
89
74
56
31
25
24
11
10
7
6
3
3
3
3
2
2
2
Supplier
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Immunogen This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Clone 288CT11-7-1
Isotype IgM, kappa
Specificity This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Purification Ascites
Alternative Name HIF1A (HIF1A Antibody Abstract)
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Synonyms: HIF1A,Hypoxia-inducible factor 1-alpha,BHLHE78, MOP1, PASD8
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody (ABIN659179) HIF1A western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates ...
Background publications Espinosa, José Carnicer, Catasus et al.: "Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role." in: The American journal of surgical pathology, Vol. 34, Issue 11, pp. 1708-14, 2010 (PubMed).

Gonsalves, Kalra: "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6253-64, 2010 (PubMed).

Hindryckx, De Vos, Jacques et al.: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, 2010 (PubMed).

Shen, Zhang, Liu et al.: "Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia." in: FEBS letters, Vol. 584, Issue 20, pp. 4366-72, 2010 (PubMed).

Corzo, Condamine, Lu et al.: "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment." in: The Journal of experimental medicine, Vol. 207, Issue 11, pp. 2439-53, 2010 (PubMed).