Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody

Details for Product No. ABIN659179
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Antigen
Synonyms HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hif1a, HIF1-alpha, HIF-1a, HIF1a, hif-1a
Reactivity
Human
(244), (101), (80), (56), (38), (34), (20), (19), (17), (16), (12), (2), (2), (2), (1), (1)
Host
Mouse
(174), (111), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(27), (14), (12), (12), (12), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(230), (79), (79), (67), (58), (50), (36), (28), (15), (11), (10), (9), (7), (4), (1), (1)
Pubmed 5 references available
Catalog no. ABIN659179
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Clone 288CT11-7-1
Isotype IgM, kappa
Specificity This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Purification Ascites
Alternative Name HIF1A
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Synonyms: HIF1A,Hypoxia-inducible factor 1-alpha,BHLHE78, MOP1, PASD8
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody HIF1A western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the HIF1A antibody detected the HIF1A protein (arrow).
Background publications Corzo, Condamine, Lu et al.: "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment." in: The Journal of experimental medicine, Vol. 207, Issue 11, pp. 2439-53, 2010 (PubMed).

Shen, Zhang, Liu et al.: "Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia." in: FEBS letters, Vol. 584, Issue 20, pp. 4366-72, 2010 (PubMed).

Hindryckx, De Vos, Jacques et al.: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, 2010 (PubMed).

Gonsalves, Kalra: "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6253-64, 2010 (PubMed).

Espinosa, José Carnicer, Catasus et al.: "Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role." in: The American journal of surgical pathology, Vol. 34, Issue 11, pp. 1708-14, 2010 (PubMed).

Hosts (174), (111), (2), (1)
Reactivities (244), (101), (80), (56), (38), (34), (20), (19), (17), (16), (12), (2), (2), (2), (1), (1)
Applications (230), (79), (79), (67), (58), (50), (36), (28), (15), (11), (10), (9), (7), (4), (1), (1)
Conjugates (27), (14), (12), (12), (12), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (36), (23), (15), (10), (8), (7), (7), (6), (6), (6), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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