Retinoblastoma 1 antibody (N-Term)
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- Target See all Retinoblastoma 1 (RB1) Antibodies
- Retinoblastoma 1 (RB1)
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Rabbit, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Retinoblastoma 1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE
- Predicted Reactivity
- Cow: 93%, Human: 100%, Mouse: 80%, Pig: 93%, Rabbit: 93%, Rat: 79%
- Characteristics
- This is a rabbit polyclonal antibody against RB1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human RB1
- Top Product
- Discover our top product RB1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 928 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Retinoblastoma 1 (RB1)
- Alternative Name
- RB1 (RB1 Products)
- Synonyms
- OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
- Background
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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Alias Symbols: OSRC, RB, pRb, pp110, p105-Rb
Protein Interaction Partner: RAF1, E2F1, ABL1, HDAC1, KDM2A, SMARCA4, USP7, UBC, DYRK1A, NEFM, DYRK1B, MAGEA11, ENC1, PPP1CA, CDKN1C, CDKN1A, CDK6, CDK4, CDK2, CCNE1, CCNA2, CCND1, HDAC11, PAX5, HIF1A, E2F4, CEBPE, CCNA1, SUMO1, UBE2I, TFAP2A, CDK3, CDK1, CCNC, CCNB1, MRPS18B, SUMO2,
Protein Size: 928 - Molecular Weight
- 106 kDa
- Gene ID
- 5925
- NCBI Accession
- NM_000321, NP_000312
- UniProt
- P06400
- Pathways
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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