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HLA Class I Histocompatibility Antigen, alpha Chain E (HLAE) (Heavy Chain) antibody

Details for Product No. ABIN94352, Supplier: Log in to see
Antigen
  • EA1.2
  • EA2.1
  • HLA-6.2
  • MHC
  • QA1
  • major histocompatibility complex, class I, E
  • HLA-E
Alternatives
anti-Human HLA Class I Histocompatibility Antigen, alpha Chain E antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
Heavy Chain
21
15
7
6
5
3
3
2
2
2
1
1
1
Reactivity
Human, Non-Human Primate
137
6
6
4
4
1
1
Host
Mouse
92
45
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
7
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
67
60
44
43
39
16
13
4
4
2
1
1
Options
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Immunogen Recombinant human HLA-E denaturated heavy chain.
Clone MEM-E-02
Isotype IgG1
Specificity The antibody MEM-E/02 specifically reacts with denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on the surface of all human cell types.
Purification Purified from ascites by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Alternative Name HLA-E (HLAE Antibody Abstract)
Research Area Major Histocompatibility Complex (MHC), Immunology
Pathways Regulation of Leukocyte Mediated Immunity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Platonova, Cherfils-Vicini, Damotte, Crozet, Vieillard, Validire, André, Dieu-Nosjean, Alifano, Régnard, Fridman, Sautès-Fridman, Cremer: "Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma." in: Cancer research, Vol. 71, Issue 16, pp. 5412-22, 2011 (PubMed).

Lo Monaco, Tremante, Cerboni, Melucci, Sibilio, Zingoni, Nicotra, Natali, Giacomini: "Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells." in: Neoplasia (New York, N.Y.), Vol. 13, Issue 9, pp. 822-30, 2011 (PubMed).

Dambaeva, Bondarenko, Grendell, Kravitz, Durning, Golos: "Non-classical MHC-E (Mamu-E) expression in the rhesus monkey placenta." in: Placenta, Vol. 29, Issue 1, pp. 58-70, 2008 (PubMed).

Menier, Saez, Horejsi, Martinozzi, Krawice-Radanne, Bruel, Le Danff, Reboul, Hilgert, Rabreau, Larrad, Pla, Carosella, Rouas-Freiss: "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules." in: Human immunology, Vol. 64, Issue 3, pp. 315-26, 2003 (PubMed).