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Antibodies
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anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (pSer727) a...
Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) (pSer727) antibody
| Antigen |
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| Synonyms |
ISGF-3, STAT91, DKFZp686B04100, AA408197, 2010005J02Rik, IMUP, H2RSP, IMUP-1, IMUP-2 |
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Epitope
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| Clonality |
Monoclonal (PSM1) |
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Host
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Reactivity
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Application
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 Alternatives Immunoprecipitation (IP), Western Blotting (WB)
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| Catalog no. |
ABIN94473 |
| Quantity |
0.1 mg (1 mg/ml) |
| Price |
325.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 3 to 5 Business Days |
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Alternative name
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STAT1 (Phospho-Ser727)
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Immunogen
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STAT1 peptide sequence 721-733 (Ser727 phosphorylated).
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Format
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Purified
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Isotype
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IgG1 (Matching secondary antibodies)
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Clone
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PSM1
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Description
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STAT1 (signal transducer and activator of transcription 1) is a transcription factor that playsimportant roles in growth arrest, apoptosis promoting and tumour suppression. After ligationof cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 orJAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimersserve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is alsophosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation.However, the both modifications are important for its maximal transcriptional activity. On theother hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.
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Specificity
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The antibody PSM1 recognizes transcriptional factor STAT1 (91 kDa) activated byphosphorylation at Ser727.
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Concentration
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1 mg/ml
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Purity
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> 95% (by SDS-PAGE)
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Purification
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Purified from hybridoma culture supernatant by protein-A affinity chromatography.
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Buffer
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Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
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Storage
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Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
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Restrictions
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For Research Use only
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Alternatives for antigen "Signal Transducer and Activator of Transcription 1, 91kDa (STAT1)", type "Antibodies"
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Hosts
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Rabbit (28), Goat (1), Mouse (1)
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Reactivities
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Human (30), Mouse (Murine) (28), Rat (Rattus) (27), Cow (Bovine) (1)
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Applications
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Western Blotting (WB) (30), Immunohistochemistry (IHC) (23), Immunoprecipitation (IP) (7), ELISA (6), Immunofluorescence (IF) (3), Enzyme Immunoassay (EIA) (1), Flow Cytometry (FACS) (1), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1)
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Epitopes
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pSer727 (5), pTyr701 (5), alpha (2), C-Term alpha (1), alpha beta (1), pY701 (1)
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