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EIF4EBP1 antibody (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) (Middle Region)

Details for Product anti-EIF4EBP1 Antibody No. ABIN950187, Supplier: Log in to see
Antigen
  • 153432_at
  • 43-BP
  • 4E-BP
  • 4E-BP1
  • 4EBP
  • 4e-bp
  • 4eBP
  • 4ebp
  • BcDNA.HL08053
  • BcDNA:HL08053
  • CG8846
  • CT8705
  • Dm 4E-BP
  • Dmel\\CG8846
  • Phas1
  • Thor/EIF4EBP
  • anon-WO0172774.158
  • d4E-BP
  • d4E-BP1
  • d4EBP
  • d4e-bp
  • d4eBP
  • dthor
  • eIF4E-BP
  • l(2)06270
  • l(2)k07736
  • l(2)k13517
  • pp20
  • thor
  • EIF4EBP1
  • fc04h09
  • wu:fc04h09
  • zgc:64137
  • 4EBP1
  • BP-1
  • PHAS-I
  • 4e-bp1
  • AA959816
  • CG8846 gene product from transcript CG8846-RA
  • eukaryotic translation initiation factor 4E binding protein 1
  • Thor
  • EIF4EBP1
  • eif4ebp1
  • LOC100230789
  • Eif4ebp1
Alternatives
anti-Human EIF4EBP1 antibody for Western Blotting
Epitope
Middle Region
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1
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1
1
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Reactivity
Human
439
233
192
11
8
5
2
2
1
1
1
Host
Rabbit
383
95
4
Clonality
Polyclonal
Conjugate
This EIF4EBP1 antibody is un-conjugated
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16
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5
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5
1
1
1
1
1
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1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
319
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199
89
56
28
18
15
14
6
5
5
3
3
3
1
Options
Supplier
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Isotype Ig
Specificity This antibody reacts to EIF4EBP1.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name EIF4EBP1 / 4E-BP1 (EIF4EBP1 Antibody Abstract)
Background This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].Synonyms: Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-1, PHAS-I, PHAS1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, eIF4E-binding protein 1
Molecular Weight 12580 Da
Gene ID 1978
NCBI Accession NP_004086
Pathways MAPK Signaling, PI3K-Akt Signaling, RTK Signaling, AMPK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-EIF4EBP1 antibody (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) (Middle Region) (ABIN950187) EIF4EBP1 Antibody (Center) immunohistochemistry analysis in formalin fixed and ...
Western Blotting (WB) image for anti-EIF4EBP1 antibody (Eukaryotic Translation Initiation Factor 4E Binding Protein 1) (Middle Region) (ABIN950187) Western blot analysis of EIF4EBP1 (arrow) using rabbit polyclonal EIF4EBP1 Anti...
Background publications She, Halilovic, Ye, Zhen, Shirasawa, Sasazuki, Solit, Rosen: "4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors." in: Cancer cell, Vol. 18, Issue 1, pp. 39-51, 2010 (PubMed).

Aoyagi, Gaspar, Shenk: "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2640-5, 2010 (PubMed).