Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (Middle Region) antibody

Details for Product No. ABIN950187
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Antigen
Synonyms
153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Dmel\\CG8846, Phas1, Thor/EIF4EBP, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, d4e-bp, ... show more
153432_at, 43-BP, 4E-BP, 4E-BP1, 4EBP, 4e-bp, 4eBP, 4ebp, BcDNA.HL08053, BcDNA:HL08053, CG8846, CT8705, Dm 4E-BP, Dmel\\CG8846, Phas1, Thor/EIF4EBP, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, d4e-bp, d4eBP, dthor, eIF4E-BP, l(2)06270, l(2)k07736, l(2)k13517, pp20, thor, EIF4EBP1, fc04h09, wu:fc04h09, zgc:64137, 4EBP1, BP-1, PHAS-I, 4e-bp1, AA959816 show less
Epitope
Middle Region
(43), (25), (24), (22), (19), (18), (18), (18), (13), (12), (11), (10), (9), (8), (7), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(367), (241), (190), (60), (60), (37), (24), (1)
Host
Rabbit
(345), (56), (21)
Clonality
Polyclonal
Conjugate
Un-conjugated
(21), (18), (11), (10), (7), (7), (7), (7), (7), (7), (7), (7), (3), (3)
Application
ELISA, Western Blotting (WB)
(275), (170), (157), (82), (69), (35), (23), (21), (12), (9), (6), (2), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN950187
357.50 $
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Specificity This antibody reacts to EIF4EBP1.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name EIF4EBP1 / 4E-BP1
Background This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].
Alternate names: Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-1, PHAS-I, PHAS1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, eIF4E-binding protein 1
Gene ID 1978
NCBI Accession NP_004086
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Aoyagi, Gaspar, Shenk: "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2640-5, 2010 (PubMed).

She, Halilovic, Ye et al.: "4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors." in: Cancer cell, Vol. 18, Issue 1, pp. 39-51, 2010 (PubMed).

Validation Images
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