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TEK antibody (TEK Tyrosine Kinase, Endothelial) (AA 19-745)

Details for Product anti-TEK Antibody No. ABIN951222, Supplier: Log in to see
Antigen
  • TEK
  • DKFZp469E064
  • AA517024
  • Cd202b
  • Hyk
  • Tie2
  • tie-2
  • CD202B
  • TIE-2
  • TIE2
  • VMCM
  • VMCM1
  • Tie-2
  • tie2
Alternatives
anti-Human TEK antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 19-745
30
23
22
20
17
13
12
10
9
7
6
6
5
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
246
125
72
6
6
2
2
1
Host
Rabbit
176
74
24
3
2
2
Clonality
Polyclonal
Conjugate
This TEK antibody is un-conjugated
19
14
12
8
7
7
6
5
4
4
4
4
4
4
3
Application
Western Blotting (WB)
145
122
60
46
44
24
20
15
11
9
6
6
4
4
3
1
Supplier
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Immunogen Highly pure (>95%) recombinant Human soluble TIE-2 (Thr19-Lys745) derived from Insect cells.
Isotype IgG
Specificity Recognizes TIE-2 (CD202b/TEK)
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Protein A Chromatography
Alternative Name CD202b / TEK (TEK Antibody Abstract)
Background TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/TEK comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2), which bind TIE-2 with high affinity have been identified. Ang2 has been reported to act as an antagonist for Ang1. Mice engineered to overexpress Ang2 or to lack Ang1 or TIE-2 display similar angiogenic defects.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
Gene ID 7010
NCBI Accession NP_000450
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways RTK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
Buffer PBS, pH 7.2
Storage 4 °C/-20 °C
Storage Comment The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TEK antibody (TEK Tyrosine Kinase, Endothelial) (AA 19-745) (ABIN951222) Western analysis of recombinant Human and Mouse sTIE-1 and sTIE-2 using a Polyclonal ...
Background publications Procopio, Pelavin, Lee et al.: "Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 30196-201, 1999 (PubMed).

Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." in: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, 1999 (PubMed).

Takakura, Huang, Naruse et al.: "Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis." in: Immunity, Vol. 9, Issue 5, pp. 677-86, 1998 (PubMed).