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conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 500-590) antibody

Details for Product No. ABIN965896
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Antigen
Synonyms ikk, ikk1, ikka, ikkalpha, CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, AI256658, Chuk1, Fbx24, Fbxo24, Ikka, zgc:56539
Epitope
AA 500-590
(35), (28), (22), (14), (12), (11), (10), (10), (9), (8), (8), (7), (7), (7), (7), (6), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(259), (99), (92), (48), (24), (24), (24), (12), (1)
Host
Mouse
(221), (41), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), ELISA
(219), (108), (56), (43), (40), (39), (30), (26), (6), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN965896
371.25 $
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Immunogen Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.
Clone 7C10B6-1A10A10
Isotype IgG1
Purification Ascitic fluid
Alternative Name CHUK
Background CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms: IKK1, IKKA, IKBKA
Gene ID 1147
Application Notes Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Prajapati, Verma, Yamamoto et al.: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, 2004 (PubMed).

Soond, Terry, Colbert et al.: "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB." in: Molecular and cellular biology, Vol. 23, Issue 22, pp. 8334-44, 2003 (PubMed).

Park, Krishnan, OMalley et al.: "Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation." in: Molecular cell, Vol. 18, Issue 1, pp. 71-82, 2005 (PubMed).

Validation Images
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