IKK alpha antibody

Catalog No. ABIN969056

There is 1 publication for this product available. The Mouse Monoclonal anti-IKK alpha antibody is suitable to detect IKK alpha in samples from Human. It has been validated for WB, ELISA, ICC and FACS.

Quick Overview for IKK alpha antibody (ABIN969056)

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IKK alpha antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 3G12H9

Product Details anti-IKK alpha Antibody

Purpose: CHUK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CHUK expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IKK alpha antibody (ABIN969056)

Wu, Jan, Tsay, Yu, Huang, Lin, Liu, Chen, Lo, Yu: "Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling." in: Molecular cancer, Vol. 9, pp. 283, (2010) (PubMed).

Target Details for IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Alternative Name: CHUK

Background: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Molecular Weight: 85 kDa

Gene ID: 1147

UniProt: O15111

Pathways: PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins