JAK2 antibody (Janus Kinase 2)

Details for Product anti-JAK2 Antibody No. ABIN966432, Supplier: Log in to see
Antigen
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Alternatives
anti-Human JAK2 antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This JAK2 antibody is un-conjugated
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1
Application
Immunohistochemistry (IHC)
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Options
Supplier
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 221 (Q-D-YP-H-I).
Specificity JAK2 (Ab-221) antibody detects endogenous levels of total JAK2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative Name JAK2 (JAK2 Antibody Abstract)
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded protein response
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Feener, Rosario, Dunn, Stancheva, Myers: "Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4968-78, 2004 (PubMed).

Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004 (PubMed).

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