Western Bloting: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Nolens, Pignon, Koopmansch, Elmoualij, Zorzi, De Pauw, Winkler: "Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines." in: Breast cancer research : BCR, Vol. 11, Issue 6, pp. R83, (2010) (PubMed).
Ohno, Kunimoto, Nishizuka, Osada, Imagawa: "Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression." in: Biochemical and biophysical research communications, Vol. 390, Issue 3, pp. 738-42, (2009) (PubMed).
Target
XRCC5
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by nonhomologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Synonyms: KU80, KUB2, Ku86, NFIV, KARP1, KARP-1, FLJ39089