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Details for Product No. ABIN967898

IP 3R-3 (AA 22-230) antibody

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Antigen
Epitope
AA 22-230
Reactivity
Human
Host
Mouse
Clonality (Clone) Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
Pubmed 5 references available
Catalog no. ABIN967898
Quantity 50 µg
Price
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Immunogen Human IP3R-3
Clone 2
Isotype IgG2a
Cross-Reactivity Cow (Bovine), Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Background Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for many hormones, growth factors, and neurotransmitters. IP3 causes the release of Ca2+ from intracellular stores by binding specific receptors that are coupled to Ca2+ channels. A number of studies have identified a family of at least four IP3 receptors (IP3R). The type III receptor (IP3R-3) has been isolated and characterized in human and rat. IP3 receptors are commonly localized in the endoplasmic reticulum, but have also been identified in the nucleus and the plasma membrane. Co-expression of different IP3 receptors is detected in most tissues and cell lines. Although these receptors appear to have a similar specificity for inositol phosphates, the different receptors have been reported to have different affinities for IP3 as follows: type II > type I > type III. This antibody is routinely tested by western blot analysis.
Synonyms: Inositol 1,4,5-triphosphate receptor type III
Molecular Weight 300 kDa
Comment

Related Products: ABIN968535, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Maranto: "Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium." in: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1222-30, 1994 (PubMed).

Blondel, Takeda, Janssen et al.: "Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues." in: The Journal of biological chemistry, Vol. 268, Issue 15, pp. 11356-63, 1993 (PubMed).

Pin, Rukstalis, Johnson et al.: "The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity." in: The Journal of cell biology, Vol. 155, Issue 4, pp. 519-30, 2001 (PubMed).

Zanner, Hapfelmeier, Gratzl et al.: "Intracellular signal transduction during gastrin-induced histamine secretion in rat gastric ECL cells." in: American journal of physiology. Cell physiology, Vol. 282, Issue 2, pp. C374-82, 2002 (PubMed).

Leite, Thrower, Echevarria et al.: "Nuclear and cytosolic calcium are regulated independently." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2975-80, 2003 (PubMed).

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