PAI1 antibody (AA 207-329)
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- Target See all PAI1 (SERPINE1) Antibodies
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
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Binding Specificity
- AA 207-329
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Reactivity
- Human, Mouse, Rat, Dog, Chicken
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PAI1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Cross-Reactivity
- Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
- Characteristics
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human PAI-1 aa. 207-329
- Clone
- 41-PAI
- Isotype
- IgG1
- Top Product
- Discover our top product SERPINE1 Primary Antibody
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- Comment
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Related Products: ABIN968536, ABIN967389
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store undiluted at -20°C.
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Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke." in: Circulation, Vol. 106, Issue 22, pp. 2854-8, (2002) (PubMed).
: "The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 777-84, (2001) (PubMed).
: "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells." in: The Journal of clinical investigation, Vol. 78, Issue 6, pp. 1673-80, (1986) (PubMed).
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Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke." in: Circulation, Vol. 106, Issue 22, pp. 2854-8, (2002) (PubMed).
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- Target
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
- Alternative Name
- PAI-1 (SERPINE1 Products)
- Synonyms
- PAI antibody, PAI-1 antibody, PAI1 antibody, PLANH1 antibody, SERPINE1 antibody, si:ch211-138a11.1 antibody, Planh1 antibody, PAI1A antibody, Pai1 antibody, Pai1aa antibody, Planh antibody, RATPAI1A antibody, serpin family E member 1 antibody, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog antibody, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 antibody, serine (or cysteine) peptidase inhibitor, clade E, member 1 antibody, SERPINE1 antibody, serpine1.L antibody, serpine1 antibody, Serpine1 antibody
- Background
- Fibrinolysis is regulated by the plasminogen activators, tissue plasminogen activator (tPA) and urokinase PA (uPA), and by the plasminogen activator-inhibitors (PAIs). Two PAIs include the serpin family members, PAI-1 and PAI-2. PAI-1 is a glycoprotein found in plasma, platelets, endothelial cells, hepatoma cells, and fibrosarcoma cells. Thrombin, endotoxin, and IL-1 induce PAI-1 synthesis in endothelial cells, which is where the major portion of plasma PAI-1 is produced. PAI-2 is a glycoprotein expressed in placenta and monocyte macrophages. The uPA/plasmin system may play a key role in cancer progression through degradation of the extracellular matrix during tumor cell migration. Paradoxically, high levels of PAI-1 are also predictive of poor prognosis of cancer patients. This finding may be a result of the role of plasmin proteolysis in the prevention of tumor vessel assembly. PAI-1 can promote tumor angiogenesis, and the mechanism may involve PAI-induced regulation of plasmin proteolysis during tumor angiogenesis. Thus, PAI-1 is a serpin protease inhibitor that is important for the regulation of plasmin proteolysis during fibrinolysis and extracellular matrix degradation.
- Molecular Weight
- 47 kDa
- Pathways
- p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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