E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial))

Details for Product anti-CDH1 Antibody No. ABIN969037, Supplier: Log in to see
Antigen
  • Arc-1
  • CD324
  • CDHE
  • ECAD
  • LCAM
  • UVO
  • E-cadherin
  • cdh1
  • si:dz180o5.2
  • dZ71B9.1
  • si:dz180o5.1
  • uvo
  • lcam
  • E-Cad
  • XBcad
  • l-cam
  • xcdh1
  • cdhc-A
  • xb-cad
  • XTCAD-1
  • c-cadherin
  • cadherin-1
  • uvomorulin
  • XB-cadherin
  • CDH1
  • CDH16
  • HPT-1
  • HPT1
  • arc-1
  • cd324
  • cdhe
  • ecad
  • cad17
  • hpt1
  • cdh16
  • hpt-1
  • LI-cadherin
  • cadherin-17
  • b-cadherin
  • cdh1-a
  • cdhp
  • hjmd
  • pcad
  • AA960649
  • E-cad
  • Ecad
  • L-CAM
  • Um
  • Arc1
  • cadherin 1, type 1, E-cadherin (epithelial)
  • si:busm1-180o5.2
  • cadherin 1, epithelial
  • cadherin 1
  • si:busm1-180o5.1
  • cadherin 17, LI cadherin (liver-intestine)
  • Cadherin-17
  • cadherin 3, type 1, P-cadherin (placental)
  • E-cadherin-like
  • Aerobic running capacity QTL 1
  • CDH1
  • si:busm1-180o5.2
  • cdh1
  • Cdh1
  • si:busm1-180o5.1
  • CDH17
  • cad17
  • cdh17
  • cdh3-a
  • LOC100356548
  • Arunc1
Alternatives
anti-Human E-cadherin antibody for Immunofluorescence (fixed cells)
Reactivity
Human, Mouse (Murine), Monkey
789
237
146
39
26
16
9
8
8
6
5
4
3
1
1
1
1
1
1
1
1
1
Host
Mouse
531
267
37
22
2
Clonality (Clone)
Monoclonal ()
Conjugate
This E-cadherin antibody is un-conjugated
42
38
33
23
20
20
16
15
15
15
14
12
12
12
12
11
11
11
9
8
7
7
6
4
3
3
3
3
3
3
2
2
Application
ELISA, Western Blotting (WB)
623
351
270
200
173
172
159
89
87
38
14
14
13
10
10
7
6
6
4
2
2
2
2
2
1
1
1
1
Options
Supplier
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Immunogen Purified recombinant fragment of human CDH1 expressed in E. Coli.
Clone 7A2
Isotype IgG1
Purification Ascites
Alternative Name CDH1 (CDH1 Antibody Abstract)
Background E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Molecular Weight 135 kDa
Gene ID 999
HGNC 999
Research Area Proteolysis / Ubiquitin
Pathways Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Western Blotting (WB) image for anti-E-cadherin antibody (Cadherin 1, Type 1, E-Cadherin (Epithelial)) (ABIN969037) Figure 1: Western blot analysis using CDH1 mouse mAb against LNCAP (1) ,A431 (2), DU1...
Product cited in: Schietke, Warnecke, Wacker, Schödel, Mole, Campean, Amann, Goppelt-Struebe, Behrens, Eckardt, Wiesener: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, 2010 (PubMed).

Barrett, Lee, Lees, Prescott, Anderson, Phillips, Wesley, Parnell, Zhang, Drummond, Nimmo, Massey, Blaszczyk, Elliott, Cotterill, Dallal, Lobo, Mowat, Sanderson, Jewell, Newman, Edwards, Ahmad et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, 2009 (PubMed).

Wang, Yao, Zhang, Zhang, Zhao: "[Expression and significance of CD147 and E-cadherin in human gastric carcinoma]." in: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 31, Issue 7, pp. 515-9, 2009 (PubMed).