Browse our anti-NUMB (NUMB) Antibodies

Full name:
anti-Numb Homolog Antibodies (NUMB)
On www.antibodies-online.com are 184 Numb Homolog (NUMB) Antibodies from 26 different suppliers available. Additionally we are shipping NUMB Proteins (11) and NUMB Kits (1) and many more products for this protein. A total of 211 NUMB products are currently listed.
Synonyms:
C14orf41, c14_5527, Nb, S171
list all antibodies Gene Name GeneID UniProt
NUMB 18222 Q9QZS3
NUMB 8650 P49757
NUMB 29419  

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Most Popular Reactivities for anti-NUMB (NUMB) Antibodies

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anti-Mouse (Murine) NUMB Antibodies:

anti-Human NUMB Antibodies:

anti-Rat (Rattus) NUMB Antibodies:

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Top referenced anti-NUMB Antibodies

  1. Human Polyclonal NUMB Primary Antibody for EIA, IHC (p) - ABIN953787 : Rennstam, McMichael, Berglund, Honeth, Hegardt, Rydén, Luts, Bendahl, Hedenfalk: Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer. in Breast cancer research and treatment 2010 (PubMed)
    Show all 5 references for 953787

  2. Human Polyclonal NUMB Primary Antibody for ELISA, WB - ABIN184679 : Zhong, Feder, Jiang, Jan, Jan: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. in Neuron 1996 (PubMed)
    Show all 3 references for 184679

  3. Human Polyclonal NUMB Primary Antibody for IHC (p), WB - ABIN655396 : Kyriazis, Wei, Vandermey, Jo, Xin, Mattson, Chan: Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. in The Journal of biological chemistry 2008 (PubMed)

  4. Chicken Polyclonal NUMB Primary Antibody for ICC, IF - ABIN152992 : Lenihan, Saha, Heimer-McGinn, Cryan, Feng, Young: Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. in Molecular neurobiology 2016 (PubMed)

  5. Human Polyclonal NUMB Primary Antibody for IF (p), IHC (p) - ABIN744428 : Mah, Soloff, Hedrick, Mariani: Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. in Stem cell reports 2015 (PubMed)

More Antibodies against NUMB Interaction Partners

Mouse (Murine) Numb Homolog (NUMB) interaction partners

  1. NUMB is necessary for establishing polarity in coelomic epithelium cells.

  2. investigations revealed that NUMB and NUMBL (show NUMBL Antibodies) interacted with small GTPase (show RACGAP1 Antibodies) Rab7 (show RAB7A Antibodies) to transition ERBB2 (show ERBB2 Antibodies) from early to late endosome for degradation.

  3. These findings highlight the importance of Numb and Numbl (show NUMBL Antibodies) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis

  4. RBM4 (show RBM4 Antibodies) depletion reduced the expression of the proneural gene Mash1 (show ASCL1 Antibodies), and such reduction was reversed by an RBM4 (show RBM4 Antibodies)-induced Numb isoform containing exon 3 but lacking exon 9. RBM4 (show RBM4 Antibodies) was also essential for neurite outgrowth from cortical neurons in vitro. Neurite outgrowth defects of RBM4 (show RBM4 Antibodies)-depleted neurons were rescued by RBM4 (show RBM4 Antibodies)-induced exon 9-lacking Numb isoforms. RBM4 (show RBM4 Antibodies) modulates exon selection of Numb.

  5. role in the mediation of TCR degradation

  6. miR (show MLXIP Antibodies)-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch (show NOTCH1 Antibodies) to separate stem and non-stem cell fates robustly.

  7. Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 (show TLR4 Antibodies).

  8. Loss of Numb induces a p53 (show TP53 Antibodies)-dependent senescence following skeletal muscle injury.

  9. Numb is a regulator for constitutive expression and dynamic transport of mGlu1 (show GRM1 Antibodies).

  10. we observed a glial reaction and an activity-dependent modification of Shh (show SHH Antibodies), Noggin (show NOG Antibodies), and Numb proteins. we found that Shh (show SHH Antibodies) and Noggin (show NOG Antibodies) could affect motor performance and that these proteins could be associated with both TDP-43 (show TARDBP Antibodies) and Numb

Human Numb Homolog (NUMB) interaction partners

  1. Low NUMB expression is associated with pancreatic cancer.

  2. Together, our findings revealed a novel function of Numb and its likely mechanism in regulation of autophagy events.

  3. investigations revealed that NUMB and NUMBL (show NUMBL Antibodies) interacted with small GTPase (show RACGAP1 Antibodies) Rab7 (show RAB7B Antibodies) to transition ERBB2 (show ERBB2 Antibodies) from early to late endosome for degradation.

  4. These findings highlight the importance of Numb and Numbl (show NUMBL Antibodies) in the control of myoepithelial cell fate determination, epithelial identity, and lactogenesis

  5. Our evidence supports a mechanism by which Numb AS is regulated in response to oncogenic signaling pathways, and contributes to activation of downstream pathways to promote tumorigenesis.

  6. Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 (show SLC1A1 Antibodies) through binding the YxNxxF (where x stands for any amino acid) motif.

  7. HBeAg and its precursors promote HDM2-mediated degradation and impair transcriptional activity of p53 (show TP53 Antibodies) by interacting with NUMB, consequently contributing to hepatocellular carcinoma development.

  8. High expression of Numb is associated with radiation resistance in pancreatic cancer.

  9. Upregulated expression of Numb is associated with reduced radiosensitivity of lung cancer.

  10. Radiation sensitivity of NSCLC stem cells was enhanced with the increase of Numb expression.

NUMB Antigen Profile

Antigen Summary

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with NUMB

  • numb gene homolog (Drosophila) (Numb) antibody
  • numb homolog (Drosophila) (NUMB) antibody
  • numb homolog (Drosophila) (Numb) antibody
  • C14orf41 antibody
  • c14_5527 antibody
  • Nb antibody
  • S171 antibody

Protein level used designations for anti-Numb Homolog (NUMB) Antibodies

protein numb homolog , h-Numb , numb gene homolog

GENE ID SPECIES
18222 Mus musculus
480381 Canis lupus familiaris
395639 Gallus gallus
8650 Homo sapiens
29419 Rattus norvegicus
512187 Bos taurus
100522019 Sus scrofa
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