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Browse our anti-SMAD3 (SMAD3) Antibodies

Full name:
anti-SMAD, Mothers Against DPP Homolog 3 Antibodies (SMAD3)
On www.antibodies-online.com are 466 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Antibodies from 28 different suppliers available. Additionally we are shipping SMAD3 Kits (46) and SMAD3 Proteins (25) and many more products for this protein. A total of 580 SMAD3 products are currently listed.
Synonyms:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all antibodies Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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Most Popular Reactivities for anti-SMAD3 (SMAD3) Antibodies

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anti-Human SMAD3 Antibodies:

anti-Mouse (Murine) SMAD3 Antibodies:

anti-Rat (Rattus) SMAD3 Antibodies:

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Top referenced anti-SMAD3 Antibodies

  1. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358226 : Venables, Bourgeois, Dalgliesh, Kister, Stevenin, Elliott: Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. in Human molecular genetics 2005 (PubMed)
    Show all 5 references for ABIN358226

  2. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358225 : Imoto, Sugiyama, Sekine, Matsuda: Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling. in FEBS letters 2005 (PubMed)
    Show all 5 references for ABIN358225

  3. Human Polyclonal SMAD3 Primary Antibody for FACS, IF - ABIN954841 : Zhang, Wang, Tan, Li, Zhang, Chen: Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN954841

  4. Chicken Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN401333 : Shi, Massagué: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. in Cell 2003 (PubMed)
    Show all 3 references for ABIN401333

  5. Human Polyclonal SMAD3 Primary Antibody for EIA, WB - ABIN401376 : Derynck, Zhang: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. in Nature 2003 (PubMed)
    Show all 3 references for ABIN401376

  6. Chicken Polyclonal SMAD3 Primary Antibody for EIA, IF - ABIN303328 : Carracedo, Lu, Popova, Jonsson, Eckes, Gullberg: The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN303328

  7. Human Polyclonal SMAD3 Primary Antibody for ELISA, WB - ABIN1531634 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for ABIN1531634

  8. Human Polyclonal SMAD3 Primary Antibody for DB, IF - ABIN389656 : Cohen-Solal, Merrigan, Chan, Goydos, Chen, Foran, Liu, Lasfar, Reiss: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition. in Pigment cell & melanoma research 2011 (PubMed)

  9. Chicken Polyclonal SMAD3 Primary Antibody for IHC, WB - ABIN2792537 : Cheng, Chang, Chao, Lee: Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. in Oncogene 2004 (PubMed)

More Antibodies against SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Antibodies) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Antibodies)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Antibodies)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Antibodies) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Antibodies) provides insight into a novel Smad (show SMAD1 Antibodies) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Antibodies)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. SMAD3 mutations reported in patients with syndromic Aortic Aneurisms and dissections with early-onset osteoarthritis.

  2. The results also revealed the existence of crosstalk between miR (show MLXIP Antibodies)-29b and TGF-beta1 (show TGFB1 Antibodies)/Smad3 during LX-2 activation, suggesting a feedback loop between miR (show MLXIP Antibodies)-29b and TGF-beta1 (show TGFB1 Antibodies)/Smad3 signalling that promotes liver fibrosis.

  3. Smad2 (show SMAD2 Antibodies) and Smad3 possess differential sensitivities in relaying TGFbeta (show TGFB1 Antibodies) signaling and have distinct roles in regulating early developmental events.

  4. Likely pathogenic variants included a TGFB2 (show TGFB2 Antibodies) variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK (show MYLK Antibodies) and MFAP5 (show MFAP5 Antibodies), which were identified in a third patient

  5. The more significant compound effects of two-locus models, combining single nucleotide polymorphisms (SNPs) in ADAM17 (show ADAM17 Antibodies) and other TGF-beta (show TGFB1 Antibodies) signaling pathway genes including TGFB2 (show TGFB2 Antibodies) and SMAD3, on KD phenotypes relative to single SNPs suggest that ADAM17 (show ADAM17 Antibodies) is also involved in secondary CAL (show FBLIM1 Antibodies) formation and confers the risk of KD/CALs (show CA8 Antibodies) via the TGF-beta (show TGFB1 Antibodies)/SMAD3 signaling pathway.

  6. Exogenous expression of miR (show MLXIP Antibodies)-142-5p inhibitor resulted in a significant reduction of viral titer indicating proviral role of miR (show MLXIP Antibodies)-142-5p. Functional studies of hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-142-5p identified its role in transforming growth factor beta (TGFbeta (show TGFB1 Antibodies)) signalling as TGFbeta (show TGFB1 Antibodies) receptor 2 and SMAD3 were degraded during both hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-142-5p overexpression and rotavirus infection.

  7. These findings pinpoint that TGF-beta (show TGFB1 Antibodies) represses miR (show MLXIP Antibodies)-30d through a Smad2 (show SMAD2 Antibodies)/3-HDAC3 (show HDAC3 Antibodies)-NCoR (show NCOR1 Antibodies) repression complex and provide novel insights into a potential target for the treatment of podocyte injury-associated glomerulopathies.

  8. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 Antibodies) pathway, and inhibition of Smad2 (show SMAD2 Antibodies)/3 signaling and Shh (show SHH Antibodies) pathways.

  10. Our study demonstrates that SMAD3 is significantly overexpressed in osteoarthritis. This overexpression cannot be explained by DNA methylation (show HELLS Antibodies) in the promoter region.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2 (show SMAD2 Antibodies)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin (show MYOCD Antibodies)-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Antibodies) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Antibodies)) gene transcription in LLC-PK1 (show PKLR Antibodies) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Activation of CB2 (show CNR2 Antibodies) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Antibodies)-mediated inhibition of TGF-beta1 (show TGFB1 Antibodies)/Smad3 pathway in mice with myocardial infarction.

  2. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 Antibodies)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Antibodies).

  3. The findings indicate that active Yap1 (show YAP1 Antibodies) promotes the self-renewal of breast Tumor initiating cells by inhibiting Smad3 signaling.

  4. Data show that muscle-specific (show EIF3K Antibodies) Smad (show SMAD1 Antibodies) proteins Smad2 (show SMAD2 Antibodies)/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  5. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2 (show SMAD2 Antibodies)/3 activity during murine cardiac progenitor cell differentiation.

  6. This study showed that Smad3 deficiency inhibits LTP (show SCP2 Antibodies) induction by enhancing phasic and tonic GABAA (show GABRg1 Antibodies) receptor-mediated neurotransmission.

  7. Suggest that hyperoxia-increased high-tidal-volume ventilation-induced acute lung injury partially depends on the Src (show SRC Antibodies) and Smad3 pathways.

  8. Smad3 is a key transcriptional factor of TGF-beta (show TGFB1 Antibodies) signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft rejection

  9. Smad2 (show SMAD2 Antibodies) and Smad3 oppositely modify STAT3 (show STAT3 Antibodies)-induced transcription of IL-17A (show IL17A Antibodies) and retinoic acid receptor (show RARA Antibodies)-related orphan nuclear receptor (show NR1D1 Antibodies), RORgammat encoded by Rorc (show RORC Antibodies), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Antibodies), respectively.

  10. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P (show S1PR1 Antibodies))/S1P3 (show S1PR3 Antibodies) signaling axis

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Antibodies)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Antibodies)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

SMAD3 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3) antibody
  • MAD homolog 3a (Drosophila) (smad3a) antibody
  • mothers against decapentaplegic homolog 3 (LOC100346303) antibody
  • SMAD family member 3 (smad3) antibody
  • SMAD family member 3 (Smad3) antibody
  • AU022421 antibody
  • HSPC193 antibody
  • HsT17436 antibody
  • JV15-2 antibody
  • LDS1C antibody
  • LDS3 antibody
  • mad3 antibody
  • Madh3 antibody
  • madh3-A antibody
  • madh3a antibody
  • Smad 3 antibody
  • smad3 antibody
  • wu:fa99e03 antibody
  • XenMLP antibody
  • Xmad3 antibody
  • XSmad3 antibody

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPECIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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