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Browse our anti-SMAD3 (SMAD3) Antibodies

Full name:
anti-SMAD, Mothers Against DPP Homolog 3 Antibodies (SMAD3)
On are 474 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Antibodies from 29 different suppliers available. Additionally we are shipping SMAD3 Kits (54) and SMAD3 Proteins (27) and many more products for this protein. A total of 598 SMAD3 products are currently listed.
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all antibodies Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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Top referenced anti-SMAD3 Antibodies

  1. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358226 : Venables, Bourgeois, Dalgliesh, Kister, Stevenin, Elliott: Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. in Human molecular genetics 2005 (PubMed)
    Show all 5 references for ABIN358226

  2. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358225 : Imoto, Sugiyama, Sekine, Matsuda: Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling. in FEBS letters 2005 (PubMed)
    Show all 5 references for ABIN358225

  3. Human Polyclonal SMAD3 Primary Antibody for FACS, IF - ABIN954841 : Zhang, Wang, Tan, Li, Zhang, Chen: Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN954841

  4. Human Polyclonal SMAD3 Primary Antibody for EIA, WB - ABIN401376 : Shi, Massagué: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. in Cell 2003 (PubMed)
    Show all 3 references for ABIN401376

  5. Chicken Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN401333 : Derynck, Zhang: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. in Nature 2003 (PubMed)
    Show all 3 references for ABIN401333

  6. Chicken Polyclonal SMAD3 Primary Antibody for EIA, IF - ABIN303328 : Carracedo, Lu, Popova, Jonsson, Eckes, Gullberg: The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN303328

  7. Human Polyclonal SMAD3 Primary Antibody for ELISA, WB - ABIN1531634 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for ABIN1531634

  8. Human Polyclonal SMAD3 Primary Antibody for DB, IF - ABIN389656 : Cohen-Solal, Merrigan, Chan, Goydos, Chen, Foran, Liu, Lasfar, Reiss: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition. in Pigment cell & melanoma research 2011 (PubMed)

  9. Dog (Canine) Polyclonal SMAD3 Primary Antibody for IHC, WB - ABIN2792537 : Cheng, Chang, Chao, Lee: Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. in Oncogene 2004 (PubMed)

More Antibodies against SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Antibodies) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Antibodies)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Antibodies)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Antibodies) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Antibodies) provides insight into a novel Smad (show SMAD1 Antibodies) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Antibodies)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Antibodies)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. signal transducer and activator of transcription (Stat (show STAT1 Antibodies))3 (show STAT3 Antibodies) represses Smad3 in synergy with the potent negative regulators of TGF-beta (show TGFB1 Antibodies) signaling, c-Ski (show SKI Antibodies) and SnoN (show SKIL Antibodies), whereby renders gefitinib-sensitive HCC827 cells resistant

  2. Therefore, our results demonstrate that autophagy counteracts the EndoMT process triggered by TGF-beta2 (show TGFB2 Antibodies) by decreasing the phosphorylation level of Smad3.

  3. Conversely, siRNA-mediated Klotho (show KL Antibodies) silencing up-regulated Egr-1 (show EGR1 Antibodies), FN, and Col (show HDAC1 Antibodies) I expression and the p-Smad3/Smad3 ratio. Moreover, the effects of si-Klotho (show KL Antibodies) on Egr-1 (show EGR1 Antibodies) expression were abolished by the TGF-beta1 (show TGFB1 Antibodies) inhibitor SB-431542. Klotho (show KL Antibodies) overexpression can prevent mesangial ECM (show MMRN1 Antibodies) production in high-glucose-treated human MCs (show SMCP Antibodies), an effect that has been partially attributed to Egr-1 (show EGR1 Antibodies) down-regulation facilitated by TGF-beta1 (show TGFB1 Antibodies)/Smad3 s...

  4. a novel STAT3 (show STAT3 Antibodies)/SMAD3-signaling axis is required for OSM (show OSM Antibodies)-mediated senescence.

  5. The protective (T) allele of rs17293632 disrupts a consensus AP-1 (show FOSB Antibodies) binding site in a SMAD3 intron 1 enhancer, reduces enhancer activity and SMAD3 expression, altering human arterial smooth muscle cell proliferation to prevent coronary artery disease.

  6. Data suggest a novel role for TGFbeta1 (show TGFB1 Antibodies)/TGFbeta (show TGFB1 Antibodies) receptor signaling via SMAD3 in regulation of expression of p16-Ink4a/Arf (show CDKN2A Antibodies) locus in beta-cells and highlight potential of using small molecule inhibitors of TGFbeta1 (show TGFB1 Antibodies)/TGFbeta (show TGFB1 Antibodies) receptor signaling to promote human b-cell proliferation. (TGFbeta1 (show TGFB1 Antibodies) = transforming growth factor beta 1 (show TGFB1 Antibodies); p16-Ink4a (show CDKN2A Antibodies) = cyclin dependent kinase inhibitor 2A (show CDKN2A Antibodies); SMAD3 = SMAD family member 3)

  7. TGF-beta (show TGFB1 Antibodies)-treated fibroblasts contained SMAD (show SMAD1 Antibodies) complexes that activated a SMAD (show SMAD1 Antibodies) target gene in addition to those repressing PPARG (show PPARG Antibodies) transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-beta (show TGFB1 Antibodies) represses PPARG (show PPARG Antibodies) transcription, thereby facilitating its own pro-fibrotic activity

  8. Our results suggested that miR (show MLXIP Antibodies)-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment.

  9. Moreover, in PAH model, Smad3, p-Smad3 and Smad4 were all downregulated in lung tissues, and SIS3 (Smad3 inhibitor) could reverse the effects of anti-miR-199a-5p in PAH rats. Our date suggest that miR-199a-5p may function as a regulator of PAH by targeting Smad3, indicating a novel therapeutic strategy for patients with PAH.

  10. Smad 3-specific reduction mediates loss of type I collagen in aged human skin.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2 (show SMAD2 Antibodies)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin (show MYOCD Antibodies)-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Antibodies) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Antibodies)) gene transcription in LLC-PK1 (show PKLR Antibodies) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

  2. hese studies revealed that Smad2 (show SMAD2 Antibodies) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Antibodies) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  3. emodin was found to increase the expression level of Sirt1 (show SIRT1 Antibodies), which decreased the level of deacetylated Smad3 to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1 (show SIRT1 Antibodies). Sirt1regulated TGFb1 (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) signaling was involved in silica inhalationinduced lung fibrosis.

  4. HSP27 (show HSPB1 Antibodies) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 Antibodies) modulates lung fibroblast differentiation through the Smad3 and ERK (show EPHB2 Antibodies) pathways.

  5. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1 (show TGFB1 Antibodies)/Smad3 signaling pathway.

  6. Notch3 (show NOTCH3 Antibodies) is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 (show NOTCH3 Antibodies) is attributable to its action on TGF-beta1 (show TGFB1 Antibodies)/Smad3 signaling.

  7. Smad3 deficiency leads to aortic aneurysms and sudden death in the Smad3 knockout animal model.

  8. TGF-beta1 (show TGFB1 Antibodies)-induced inhibition of PPARgamma (show PPARG Antibodies) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 (show HDAC1 Antibodies) at the PPARgamma (show PPARG Antibodies) promoter.

  9. Activation of CB2 (show CNR2 Antibodies) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Antibodies)-mediated inhibition of TGF-beta1 (show TGFB1 Antibodies)/Smad3 pathway in mice with myocardial infarction.

  10. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 Antibodies)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Antibodies).

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Antibodies)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Antibodies)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

SMAD3 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3) antibody
  • MAD homolog 3a (Drosophila) (smad3a) antibody
  • mothers against decapentaplegic homolog 3 (LOC100346303) antibody
  • SMAD family member 3 (smad3) antibody
  • SMAD family member 3 (Smad3) antibody
  • AU022421 antibody
  • HSPC193 antibody
  • HsT17436 antibody
  • JV15-2 antibody
  • LDS1C antibody
  • LDS3 antibody
  • mad3 antibody
  • Madh3 antibody
  • madh3-A antibody
  • madh3a antibody
  • Smad 3 antibody
  • smad3 antibody
  • wu:fa99e03 antibody
  • XenMLP antibody
  • Xmad3 antibody
  • XSmad3 antibody

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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