Browse our anti-SMAD3 (SMAD3) Antibodies

Full name:
anti-SMAD, Mothers Against DPP Homolog 3 Antibodies (SMAD3)
On are 515 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Antibodies from 30 different suppliers available. Additionally we are shipping SMAD3 Kits (57) and SMAD3 Proteins (27) and many more products for this protein. A total of 642 SMAD3 products are currently listed.
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all antibodies Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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Top referenced anti-SMAD3 Antibodies

  1. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358225 : Venables, Bourgeois, Dalgliesh, Kister, Stevenin, Elliott: Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. in Human molecular genetics 2005 (PubMed)
    Show all 5 references for 358225

  2. Human Polyclonal SMAD3 Primary Antibody for EIA, IHC (p) - ABIN358226 : Imoto, Sugiyama, Sekine, Matsuda: Roles for lysine residues of the MH2 domain of Smad3 in transforming growth factor-beta signaling. in FEBS letters 2005 (PubMed)
    Show all 5 references for 358226

  3. Chicken Polyclonal SMAD3 Primary Antibody for EIA, IF - ABIN303328 : Carracedo, Lu, Popova, Jonsson, Eckes, Gullberg: The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for 303328

  4. Human Polyclonal SMAD3 Primary Antibody for ELISA, WB - ABIN1531634 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for 1531634

  5. Human Polyclonal SMAD3 Primary Antibody for IF (p), IHC (p) - ABIN746138 : Ghiabi, Jiang, Pasquier, Maleki, Abu-Kaoud, Halabi, Guerrouahen, Rafii, Rafii: Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. in Journal of translational medicine 2015 (PubMed)
    Show all 2 references for 746138

  6. Human Polyclonal SMAD3 Primary Antibody for IF (p), IHC (p) - ABIN756832 : Zhang, Ju, Zhang, Zhu, Nie, Xu, Lei et al.: Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4(+) T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 ... in Basic & clinical pharmacology & toxicology 2016 (PubMed)

  7. Human Polyclonal SMAD3 Primary Antibody for DB, IF - ABIN389656 : Cohen-Solal, Merrigan, Chan, Goydos, Chen, Foran, Liu, Lasfar, Reiss: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-?-mediated growth inhibition. in Pigment cell & melanoma research 2011 (PubMed)

  8. Dog (Canine) Polyclonal SMAD3 Primary Antibody for IHC, WB - ABIN2792537 : Cheng, Chang, Chao, Lee: Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. in Oncogene 2004 (PubMed)

More Antibodies against SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data suggest that Clock1a (show CLOCK Antibodies) coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a (show CLOCK Antibodies) alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a (show CLOCK Antibodies) activates Smad3a promoter via its E-box1 element. (Clock1a (show CLOCK Antibodies) = clock circadian regulator (show CLOCK Antibodies) a; Nodal = nodal modulator 1 (show NOMO1 Antibodies); Smad3a = SMAD (show SMAD1 Antibodies) family member 3a)

  2. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Antibodies) control of zebrafish spinal cord development

  3. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Antibodies)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Antibodies)/3 signaling and embryonic patterning.

  4. although the role of Smad (show SMAD1 Antibodies) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Antibodies) provides insight into a novel Smad (show SMAD1 Antibodies) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  5. Smad2 (show SMAD2 Antibodies)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Antibodies)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. stablish PPM1A (show PPM1A Antibodies) as a novel repressor of the SMAD3 pathway in renal fibrosis

  2. Methylation in SMAD3 was selectively increased in asthmatic children of asthmatic mothers and was associated with childhood asthma risk

  3. a direct crosstalk between the STAT3 (show STAT3 Antibodies) and Smad3 signaling pathways that may contribute to tumor development and inflammation.

  4. It is reported here that TGF-beta (show TGFB1 Antibodies) directly regulates alternative splicing of cancer stem cell marker CD44 (show CD44 Antibodies) through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein (show PTBP1 Antibodies) PCBP1 (show PCBP1 Antibodies).

  5. Bcl-3 (show BCL3 Antibodies) knockdown enhanced the degradation of Smad3 but not Smad2 (show SMAD2 Antibodies) following TGFbeta (show TGFB1 Antibodies) treatment.

  6. miR (show MLXIP Antibodies)-206 and miR (show MLXIP Antibodies)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 (show TRIB2 Antibodies) promoter activity through p-Smad3.

  7. These studies support previously unrecognized, cooperative interaction between the CCN1 (show CCNA2 Antibodies) matricellular protein and canonical TGF-beta1 (show TGFB1 Antibodies)/SMAD3 signaling that promotes lung fibrosis.

  8. c-Abl (show ABL1 Antibodies) promotes TGF-beta (show TGFB1 Antibodies)-induced SKIP/Smad3 interaction.

  9. Substance P (show TAC1 Antibodies) can promote hepatic stem cell proliferation and induce HSC (show FUT1 Antibodies) activation via the TGF-beta1 (show TGFB1 Antibodies)/Smad3 signaling pathway.

  10. High SMAD3 expression is associated with increased lung adenocarcinoma.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Antibodies) is necessary to drive transcription of Smad2 (show SMAD2 Antibodies)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Activin A (show INHBA Antibodies) and overexpression of SMAD2 (show SMAD2 Antibodies)/3 significantly promoted expressions of porcine NANOG (show NANOG Antibodies) and OCT4 (show POU5F1 Antibodies),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Antibodies)/OCT4 (show POU5F1 Antibodies) expression.

  2. Smad3 regulate the activity and stability of myocardin (show MYOCD Antibodies)-related transcription factor during epithelial-myofibroblast transition

  3. SP1 (show SP1 Antibodies) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Antibodies)) gene transcription in LLC-PK1 (show PKLR Antibodies) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data suggest that Gas5 suppresses Tgfb1 (show TGFB1 Antibodies)/Smad3 signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 via multiple RNA Smad (show SMAD1 Antibodies)-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 (show TGFB1 Antibodies) = transforming growth factor beta 1 (show TGFB1 Antibodies); Smad3 = MAD homolog 3 protein)

  2. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta (show TGFB1 Antibodies).

  3. Soluble epoxide hydrolase (show EPHX2 Antibodies) inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38 (show CRK Antibodies)/Smad3 signaling pathway.

  4. A critical role for the Smad3-c-Jun (show JUN Antibodies) pathway in the regulation of Fstl1 (show FSTL1 Antibodies).

  5. Mirtazapine suppressed 5-HT (show DDC Antibodies)-mediated TGF-beta1 (show TGFB1 Antibodies)/Smad3 and ERK1/2 (show MAPK1/3 Antibodies) signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis.

  6. These results suggest that Nedd9 (show NEDD9 Antibodies) is a Smad2 (show SMAD2 Antibodies)/3 target gene implicated in RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.

  7. These results suggested that TGF-beta1 (show TGFB1 Antibodies)/Smad3 signaling was activated during CCl4 (show CCL4 Antibodies)-induced acute liver injury in mice, and Smad3 overexpression aggravated acute liver injury by promoting inflammatory cells infiltration, inflammatory cytokines release and hepatocytes apoptosis.

  8. gonadotropin-releasing hormone receptor (show GNRHR Antibodies) mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH (show BRD2 Antibodies) synthesis in vivo

  9. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

  10. hese studies revealed that Smad2 (show SMAD2 Antibodies) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Antibodies) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Antibodies)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Antibodies)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

SMAD3 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3) antibody
  • MAD homolog 3a (Drosophila) (smad3a) antibody
  • mothers against decapentaplegic homolog 3 (LOC100346303) antibody
  • SMAD family member 3 (smad3) antibody
  • SMAD family member 3 (Smad3) antibody
  • AU022421 antibody
  • HSPC193 antibody
  • HsT17436 antibody
  • JV15-2 antibody
  • LDS1C antibody
  • LDS3 antibody
  • mad3 antibody
  • Madh3 antibody
  • madh3-A antibody
  • madh3a antibody
  • Smad 3 antibody
  • smad3 antibody
  • wu:fa99e03 antibody
  • XenMLP antibody
  • Xmad3 antibody
  • XSmad3 antibody

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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