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This is the first demonstration of biochemical and physiological consequences caused by loss of Trx-2 in Drosophila.
gene for thioredoxin (DmTrx-2) was cloned and expressed, and the protein characterized
Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor - and poly-glutamine-induced neurotoxicity
Trx-2 affects lifespan in Drosophila. Mutants have a decreased lifespan.
The crucial role of KMT2B in the physiological control of voluntary movement.
Prx3 (show PRDX3 Proteins) and Trx2 comprise an adaptive system to sense changes in atmospheric oxygen tension and influence cellular injury responses through both detoxification of mitochondrial oxidants and regulation of mitochondrial redox-dependent signaling
Trx2 overexpression failed to attenuate hypoxia-induced human pulmonary arterial smooth muscle cells proliferation in vitro or hypoxia-induced Pulmonary hypertension in vivo.
study demonstrated that miR (show MLXIP Proteins)-27a and -b, which are widely expressed in host cells, suppress SNAP25 (show SNAP25 Proteins) and TXN2 expression through posttranscriptional gene silencing.
MLL4 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.
Results show that KMT2B interacts with ERalpha (show ESR1 Proteins) to bind the ERalpha (show ESR1 Proteins)-binding sites of IL-20 (show IL20 Proteins) and other ERalpha (show ESR1 Proteins) target genes with H3K4 modifications suggesting an important role for KMT2B in the epigenetic transcriptional regulation of cytokine IL-20 (show IL20 Proteins), and other ERalpha (show ESR1 Proteins)-responsive genes, in breast cancer cells.
findings thus establish generalized dystonia as the human phenotype associated with haploinsufficiency of KMT2B; moreover, we provide evidence for a causative role of disordered histone modification, chromatin states, and transcriptional deregulation in dystonia pathogenesis
No evidence that SNPs in TRX2 have effects, but the rs4485648 polymorphism of the TrxR2 (show TXNRD2 Proteins) gene might exert an independent effect on the development of Diabetic retinopathy.
The results explain how the MLL (show MLL Proteins) SET domains of MLL1 and MLL4 are able to add multiple methyl groups to the target histone H3 (show HIST3H3 Proteins) lysine.
The Aven RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.
The ventral signal observed from early stages colocalized with motor neuron markers Isl1 (show ISL1 Proteins)/2 and FoxP1 (show FOXP1 Proteins) and the strong ventral signal colocalizing with Isl1 (show ISL1 Proteins)/2 was observed in all rostrocaudal segments of the spinal cord.
TRX-2 overexpression does not mitigate adverse effects of a high-calorie diet on synaptic plasticity
An essential role was identified for thioredoxin-2 in preserving cardiac function by suppressing mitochondrial reactive oxygen species.
The SirT1 (show SIRT1 Proteins) regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (show SOD2 Proteins), catalase (show CAT Proteins), peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2 (show TXNRD2 Proteins), and uncoupling protein 2 (show UCP2 Proteins).
This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver and upregulated thioredoxin-2 expression.
Both thioredoxin 2 and glutaredoxin 2 (show GRX2 Proteins) contribute to the reduction of the mitochondrial 2-Cys (show DNAJC5 Proteins) peroxiredoxin Prx3 (show PRDX3 Proteins).
Data show that Nrf2 (show NFE2L2 Proteins) activity was increased in WT MEFs at the 0 or -46 mV conditions, but was inhibited in Trx2 Tg MEFs under the same conditions.
the rapid E2-mediated activation of the Txn (show TXN Proteins) pathway is an important step in the response of the mammalian uterus to estrogen.
Trx2 is an endogenous regulator of the mitochondrial permeability transition.
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
, thioredoxin, mitochondrial
, thioredoxin 2
, Thioredoxin 2
, WW domain binding protein 7
, WW domain-binding protein 7
, histone-lysine N-methyltransferase 2B
, histone-lysine N-methyltransferase MLL4
, lysine N-methyltransferase 2B
, lysine N-methyltransferase 2D
, mixed lineage leukemia gene homolog 2
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4
, myeloid/lymphoid or mixed-lineage leukemia 4
, myeloid/lymphoid or mixed-lineage leukemia protein 4
, trithorax homolog 2
, trithorax homologue 2
, mitochondrial thioredoxin
, thioredoxin nuclear gene encoding mitochondrial protein