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The interactions described herein between the beta subunit (show POLG Proteins) of PhK and GAPDH (show GAPDH Proteins) provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.
PHKb affects colorectal cancer cell growth and represents a novel prognostic biomarker.
Analysis showed that the glycogen (show GYS1 Proteins) phosphorylase kinase beta-subunit (PHKB) interacted with the C-terminal region of KIAA1199 protein.
alpha- and beta-subunits possess amino-terminal glucoamylase-like domains and suggests that they might possess a previously overlooked amylase (show AMY Proteins) activity
Interaction of the wild type (wt) heat shock protein Hsp27 and its three-dimensional (3D) mutant (mimicking phosphorylation at Ser15, 78, and 82) with rabbit skeletal muscle phosphorylase kinase (PhK) has been studied under crowding conditions.
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.
phosphorylase b kinase regulatory subunit beta
, phosphorylase kinase beta-subunit
, phosphorylase kinase subunit beta