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|Application / Reactivity||Human|
|Cellular Assay (CA)||1 Antibodies|
|Dot Blot (DB)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||8 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||14 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||13 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Western Blotting (WB)||39 Antibodies|
|Antigen||Kallikrein 6 (KLK6) Antibodies|
|Epitope||AA 91-190 Alternatives|
|Conjugate||This Kallikrein 6 antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-Kallikrein 6 AntibodyTarget Details Kallikrein 6 Application Details Handling References for anti-Kallikrein 6 Antibody (ABIN393337) Images
|Specificity||KLK6 (AAH15525, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||KLK6 (AAH15525, 91 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details Kallikrein 6Product Details anti-Kallikrein 6 Antibody Application Details Handling References for anti-Kallikrein 6 Antibody (ABIN393337) Images back to top
|Alternative Name||KLK6 (KLK6 Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||26856 DA|
|Research Area||Cancer, Neurology, Cell Structure|
Application DetailsProduct Details anti-Kallikrein 6 Antibody Target Details Kallikrein 6 Handling References for anti-Kallikrein 6 Antibody (ABIN393337) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
Background: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Kallikrein 6 Antibody Target Details Kallikrein 6 Application Details References for anti-Kallikrein 6 Antibody (ABIN393337) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-Kallikrein 6 Antibody (ABIN393337)Product Details anti-Kallikrein 6 Antibody Target Details Kallikrein 6 Application Details Handling Images back to top
Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).
Klein, Halldén, Cronin et al.: "Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer." in: Cancer prevention research (Philadelphia, Pa.), Vol. 3, Issue 5, pp. 611-9, 2010 (PubMed).
Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).
White, Mathews, Yousef et al.: "KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma." in: British journal of cancer, Vol. 101, Issue 7, pp. 1107-13, 2009 (PubMed).
Sardana, Diamandis: "The kallikrein family of proteins as urinary biomarkers for the detection of prostate cancer." in: Clinical biochemistry, Vol. 42, Issue 13-14, pp. 1483-6, 2009 (PubMed).
ImagesProduct Details anti-Kallikrein 6 Antibody Target Details Kallikrein 6 Application Details Handling References for anti-Kallikrein 6 Antibody (ABIN393337) back to top