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Fcho1/2Eps15/RAP-2 (show RAP2A Proteins) ternary complexes to facilitate conformational activation of AP-2 (show GTF3A Proteins) by the Fcho1/2 interdomain linker to promote AP-2 (show GTF3A Proteins) cargo engagement.
An interaction of Eps15 and pS227-FIP2 (show OPTN Proteins) at the appropriate time and location in polarizing cells is necessary for proper establishment of epithelial polarity.
RAB11FIP3 (show RAB11FIP3 Proteins) combines with Eps15 homology domain 1 to promote the endocytosis recycling of phosphorylation of epithelial growth factor receptor (show RYK Proteins).
Together, the data indicate that a CUL3 (show CUL3 Proteins)-SPOPL (show SPOPL Proteins) E3 ubiquitin ligase (show MUL1 Proteins) complex regulates endocytic trafficking and formation of multivesicular bodies by ubiquitinating and degrading EPS15 at endosomes.
identify USP9X (show USP9X Proteins) as a novel regulator of EGFR (show EGFR Proteins) endocytosis
over-expression of EPS15 is a potential favorable prognostic marker in breast cancer.
MLL (show MLL Proteins)-EPS15 translocation and individual genomic copy number alterations in monozygotic infant twins are associated with acute lymphoblastic leukemia.
Ubiquitin is sufficient for Eps15 recruitment to endosomes.
Results indicate that phosphorylation of epidermal growth factor receptor pathway substrate 15 (Eps15) at Ser (show SIGLEC1 Proteins)-796 is catalyzed by p38 (show CRK Proteins) directly.
distinct forms of Eps15 direct EGFR (show EGFR Proteins) to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S)
Genetic and biochemical studies of interactions with components of the endocytic machinery suggest that Eps15 has an important role in synaptic vesicle recycling and regulates recruitment of alpha-Adaptin.
Eps-15 controls synaptic vesicle membrane retrieval and synapse development.
Eps15 is a regulator of B-cell lymphopoiesis
a short amino-acid stretch at the carboxy-termini of the monoubiquitinated endocytic proteins Eps15 and eps15R is indispensable for their monoubiquitination
c-Cbl (show CBL Proteins) directs EGF (show EGF Proteins) receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15
Our results suggest that spartin (show SPG20 Proteins) might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome.
Mouse hepatitis virus type 2 entry is mediated through clathrin-dependent but Eps15-independent endocytosis
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
ALL1 fused gene from chromosome 1
, epidermal growth factor receptor substrate 15
, protein AF-1p
, Eps15 homologue 1
, epidermal growth factor receptor pathway substrate clone 15
, epidermal growth factor receptor pathway substrate 15
, epidermal growth factor receptor substrate 15-like
, epidermal growth factor pathway substrate 15