Browse our MBTPS1 Proteins (MBTPS1)

Full name:
Membrane-Bound Transcription Factor Peptidase, Site 1 Proteins (MBTPS1)
On are 6 Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1) Proteins from 2 different suppliers available. Additionally we are shipping MBTPS1 Antibodies (10) and many more products for this protein. A total of 17 MBTPS1 products are currently listed.
0610038M03Rik, AV003995, mKIAA0091, PCSK8, S1p, Ski-1, Ski1
list all proteins Gene Name GeneID UniProt
MBTPS1 8720 Q14703
MBTPS1 56453 Q9WTZ2
Rat MBTPS1 MBTPS1 89842 Q9WTZ3

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MBTPS1 Proteins (MBTPS1) by Origin

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More Proteins for MBTPS1 Interaction Partners

Human Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1) interaction partners

  1. Results suggest that (pro)renin receptor (show ATP6AP2 Proteins) (s(P)RR (show ATP6AP2 Proteins)) is generated by sequential processing by site-1 protease (S1P) and furin (show FURIN Proteins) protein.

  2. primordial SKI-1/S1P likely contained a simpler prodomain consisting of the highly conserved AB fragment that represents an independent folding unit

  3. S1P substrate-dependent regulatory mechanisms for lipid synthesis and biogenesis of lysosomes are different

  4. The interaction between S1P and C5a plays an important role in neutrophils for antineutrophil cytoplasmic antibody -mediated activation

  5. Incompletely matured forms of SKI-1/S1P further process cellular and viral substrates in distinct subcellular compartments.

  6. We show that SKI-1 is constitutively expressed in human pigment cells with higher SKI (show SKI Proteins) activity in seven out of eight melanoma cell lines compared with normal melanocytes.

  7. Diabetic high-density lipoprotein carries higher levels of S1P compared with normal high-density lipoprotein.

  8. Y285 of SKI-1 is crucial for the efficient processing of envelope glycoproteins from Old World and clade C New World arenavirus.

  9. The role of MBTPS1 (SKI-1/S1P) peptides in cancer and approaches used to inhibit SKI-1/S1P were studied.

  10. study found that the N-acetylglucosamine-1-phosphotransferase alpha/beta-subunit (show POLG Proteins) precursor is cleaved by S1P that activates sterol regulatory element-binding proteins in response to cholesterol deprivation; S1P functions in the biogenesis of lysosomes

Mouse (Murine) Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1) interaction partners

  1. Data (including data from studies in knockout mice) suggest osteocyte Mbtps1 expression is involved in development of sarcopenia in slow-twitch muscle fibers; Mbtps1 knockout mice (conditional osteocyte deletion) do not develop sarcopenia of aging.

  2. S1P (show S1PR1 Proteins) substrate-dependent regulatory mechanisms for lipid synthesis and biogenesis of lysosomes are different

  3. A novel role for MBTPS1/SKI-1/S1P (membrane bound transcription factor protease, subtilisin kexin isozyme-1, or site 1 protease) in somite segmentation and in the pathogenesis of vertebral anomalies.

  4. These studies indicate an indispensable role for S1P in type IIB procollagen trafficking from the ER.

  5. Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice.

  6. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner

  7. the differentiated phenotype of osteoblastic cells and possibly osteocytes depends upon the non-apoptotic actions of SKI-1.

  8. S1P (show S1PR1 Proteins) affects and sustains all key cellular processes responsible for wound repair and point to a unique potential for this molecule in the therapy of diabetic wounds, particularly as an angiogenic agent in treatment of diabetic wounds.

  9. Site-1 protease is essential for endochondral bone formation.

  10. SKI-1 plays a direct or indirect role in assembly of functional nucleation complexes containing BAG-75 and BSP (show KLK6 Proteins) and their fragments, thus facilitating initial mineral nucleation within these biomineralization foci.

MBTPS1 Protein Profile

Protein Summary

The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein.

Alternative names and synonyms associated with MBTPS1

  • membrane-bound transcription factor peptidase, site 1 (MBTPS1)
  • membrane-bound transcription factor peptidase, site 1 (Mbtps1)
  • 0610038M03Rik protein
  • AV003995 protein
  • mKIAA0091 protein
  • PCSK8 protein
  • S1p protein
  • Ski-1 protein
  • Ski1 protein

Protein level used designations for MBTPS1

endopeptidase S1P , membrane-bound transcription factor site-1 protease , site-1 protease , subtilisin/kexin isozyme-1 , S1P endopeptidase , membrane-bound transcription factor protease, site 1 , sterol-regulated luminal protease , subtilisin/kexin isozyme 1 , subtilisin/kexin isozyme SKI-1

8720 Homo sapiens
56453 Mus musculus
89842 Rattus norvegicus
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