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Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors.
results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment
SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China.
DNA methylation (show HELLS Proteins) at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription.
two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling
MCHR1 expression level was 1.6 times higher in vitiligo (show MITF Proteins) uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin.
data suggest that RGS2 (show RGS2 Proteins) and RGS8 (show RGS8 Proteins) differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo
Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone (show PMCH Proteins) action at human melanin-concentrating hormone receptor 1.
MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells.
MCHR1 is expressed and functional in human skin
MCH1 (show CAP1 Proteins)-Rs regulate the rewarding properties of alcohol through interactions with signaling cascades in the nucleus accumbens shell.
The present work is the first study to systematically compare the effects of MCH (show PMCH Proteins) signaling on behavioral and metabolic phenotypes.[Meta-analysis]
This study supports the use of the Mchr1-cre mouse for outlining the neuroanatomical distribution and neurochemical phenotype of MCHR1 neurons.
This study demonistrated that lack of MCH (show PMCH Proteins) receptor provoked a ventricular size increase and beat frequency of ependymal cilia.
Mchr1 and Sstr3 (show SSTR3 Proteins) are expressed and colocalized within cilia in multiple mouse brain regions, and they form heteromers.
Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function
The elevated basal body temperature and reduction in NREM sleep time resulting from shorter NREM episode durations observed in knockout mice suggests that central MCH (show PMCH Proteins)(1) receptor has a role in thermoregulation and presumably stabilization of NREM sleep.
Data show that the melanin-concentrating hormone (show PMCH Proteins)/MCH1R system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption.
In melanin-concentrating hormone receptor 1 knock-out mice, long-term synaptic depression was strongly diminished in hippocampus.
The data indicate that the MCH (show PMCH Proteins) system is involved in the regulation of PTZ and pilocarpine seizure threshold.
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
G protein-coupled receptor 24
, MCH receptor 1
, somatostatin receptor-like protein
, G protein coupled receptor 24
, G-protein coupled receptor 24
, Gpr24-9 protein coupled receptor
, melanin-concentrating hormone receptor subtype 1