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Dog (Canine) Monoclonal SLC9A1 Primary Antibody for IF, WB - ABIN968660
Aharonovitz, Zaun, Balla, York, Orlowski, Grinstein: Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. in The Journal of cell biology 2000
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Dog (Canine) Monoclonal SLC9A1 Primary Antibody for IF, WB - ABIN968659
Cox, Lutz, Yang, Biemesderfer, Bronson, Fu, Aronson, Noebels, Frankel: Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. in Cell 1997
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Human Polyclonal SLC9A1 Primary Antibody for IHC, ELISA - ABIN1002913
Mendoza: The Na+-H+ antiport is a mediator of cell proliferation. in Acta paediatrica Scandinavica 1987
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Human Polyclonal SLC9A1 Primary Antibody for IHC, ELISA - ABIN1002914
Denker, Huang, Orlowski, Furthmayr, Barber: Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. in Molecular cell 2001
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Arabidopsis thaliana Polyclonal SLC9A1 Primary Antibody for ELISA, WB - ABIN3197494
Chen, Xiao, Wu, Dong, He, Pei, Zheng: Nitric oxide enhances salt secretion and Na(+) sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H(+)-ATPase and Na(+)/H(+) antiporter under high salinity. in Tree physiology 2010
Fish Monoclonal SLC9A1 Primary Antibody for WB - ABIN2475808
Rutherford, Pizzonia, Biemesderfer, Abu-Alfa, Reilly, Aronson: Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. in Experimental nephrology 1998
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Co-overexpression of AtNHX1 and SOS1 (show SOS1 Antibodies) could significantly reduce yield loss caused by the combined stresses of heat and salt, confirming the hypothesis that stacked overexpression of two genes could substantially improve tolerance against multiple stresses.
Tonoplast-localized NHX1 and NHX2 proteins are essential for active K+ uptake at the tonoplast, for turgor regulation, and for stomatal function.
Overexpression of AtNHX1 gene not only improved salt tolerance but also drought tolerance in transgenic groundnut.
NHX1 and NHX2 mediate K+/H+ exchange to accumulate K+ in the vacuole. NHX1 and NHX2 function together to control cell expansion in vegetative tissues and male reproductive organs and are required for normal flower development.
Studies shoe that the rutin content of the roots, stems and leaves of AtNHX1 transgenic buckwheat increased than those of the control plants.
Use of the T-DNA insertional mutant of AtNHX1 (nhx1 plants) and DNA arrays to assess differences in transcriptional profiles and further characterize the roles of this protein.
the presence of a vacuolar calmodulin-like (show KRIT1 Antibodies) protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca(2 (show CA2 Antibodies)+)- pH-dependent manner suggests the presence of signaling entities acting within the vacuole.
AtNHX1 has a role in calcium signaling, sulfur metabolism, cell structure and cell growth, as well as vesicular trafficking and protein processing.
To generate salt-tolerant turf and forage, tall fescue (Festuca arundinacea) was transformed with AtNHX1.
Lack of Dicer (show DICER1 Antibodies) leads to oxidative stress, cytosolic acidification, upregulated NHE1 expression and activity as well as swelling of CD4 (show CD4 Antibodies)+ T cells, functions all reversed by miR (show MLXIP Antibodies)-15b or miR (show MLXIP Antibodies)-200b.
DJ-1 (show PARK7 Antibodies) is a powerful regulator of reactive oxygen species production as well as NHE1 expression and activity in CD4 (show CD4 Antibodies)(+) T cells.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Inhibition of NHE1 by siRNA-NHE1 or with cariporide in CD4 (show CD4 Antibodies)(+) T helper 9 (Th9) cells down-regulated IL-9 (show IL9 Antibodies) and ATP production.
The current study concluded that NHE1 activity and pHi homeostasis are regulated by CoCl2 treatment in a time-dependent manner in astrocytes, and may be responsible for the changes in cell viability and injury observed under hypoxia-mimetic conditions induced by CoCl2 treatment.
During hypoxia, activation of ROCK enhances NHE1 activity and promotes pulmonary artery smooth muscle cell migration and proliferation.
Na/H exchanger is regulated in dendritic cells by Akt1 (show AKT1 Antibodies).
our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3 (show NFATC4 Antibodies)/Gata4 (show GATA4 Antibodies) and OPN (show SPP1 Antibodies) expression
NHE1 function is necessary for maintaining mammary branched architecture.
the extracellular matrix (ECM (show MMRN1 Antibodies)) composition strongly impacts on NHE1-dependent in vitro cell motility and invasion
This study evaluated the role for NHE-1 in diabetic cataract formation and retinal oxidative stress and apoptosis.
Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2 (show SLC9A2 Antibodies), is stimulated during ischemia to participate in cerebral edema formation.
NHE isoform switching and KChIP2 (show KCNIP2 Antibodies) upregulation takes place in aging porcine atria.
NHE-1 inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.
NHE1 is a plasma membrane transporter that uses the energy of the chemical gradient created by the Na+/K+ ATPase (show ATP1A1 Antibodies) to couple the transport of one extracellular sodium for one intracellular proton. NHE1 functional domains, functional features, protein interactions, role in cell migration, and inhibitors are reviewed. A model of its role in pH control in tumor cells is described. Review.
The transcription factor Zeb1 (show ZEB1 Antibodies) binds to the Na+/H+ exchanger 1 promoter, suggesting that Zeb1 (show ZEB1 Antibodies) directly controls Na+/H+ transcription.
NHE1 function plays an important role in glioma-microglia interactions, enhancing glioma proliferation and invasion by stimulating microglial release of soluble factors.
results demonstrate that early stop codon polymorphisms have significant and deleterious effects on the activity of the SLC9A1 protein product. The 735-NHE1 mutant, without the last 80 amino acids, had more minor defects
the accumulation of reactive oxygen species (ROS (show ROS1 Antibodies)) in cells expressing JAK2V617F compromises the NHE-1/Bcl-xL (show BCL2L1 Antibodies) deamidation pathway by repressing NHE-1 upregulation in response to DNA damage. hematopoietic stem cells (HSCs), FOXO3A (show FOXO3 Antibodies) is largely localized within the nuclei despite the presence of JAK2V617F mutation, suggesting that JAK2 (show JAK2 Antibodies)-FOXO (show FOXO3 Antibodies) signaling has a different effect on progenitors compared with stem cells.
Findings suggest that Na(+)/H(+) exchanger1 (NHE1) could be a target for anti-invasion/metastasis therapy.
These data identify a molecular mechanism for pH-sensitive PI(4,5)P2 binding regulating NHE1 activity and suggest that the evolutionarily conserved cluster of four histidines in the proximal cytoplasmic domain of NHE1 may constitute a proton modifier site.
Results indicate that Nav 1.7 promotes GC progression through MACC1 (show MACC1 Antibodies)-mediated upregulation of NHE1.
High NHE1 expression is associated with gastric cancer.
In human ovarian cancer cells the inducible nitric oxide synthase (iNOS (show NOS2 Antibodies)) is overexpressed leading to increased formation of nitric oxide (NO). The NO promotes a glycolytic phenotype (Warburg effect) leading to H+ generation, which are removed via the sodium, proton (H+) exchanger isoform 1 (NHE1) reducing the intracellular content of this acid equivalent.
In vitro phosphorylation of NHE1 C-terminal fusion proteins determined that ERK (show MAPK1 Antibodies)-dependent phosphorylation of the cytoplasmic region was not dependent on Ser (show SIGLEC1 Antibodies)(703); however, phosphorylation by p90(rsk (show RPS6KA1 Antibodies)) required Ser (show SIGLEC1 Antibodies)(703).
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth.
, Na(+)/H(+) exchanger 1
, Na+/H+ antiporter
, Na+/H+, amiloride sensitive
, slow-wave epilepsy
, sodium/hydrogen exchanger 1
, solute carrier family 9 member 1
, solute carrier family 9, member 1
, sodium proton exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
, Solute carrier family 9 member 1
, NA(+)-H+ exchanger protein
, Na-Li countertransporter
, Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)
, solute carrier family 9 (sodium/hydrogen exchanger), member 1
, Na+/H+ exchanger
, pH regulatory protein (Na(+) /H(+) exchanger)