Browse our anti-Methyl CpG Binding Protein 2 (MECP2) Antibodies

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anti-Methyl CpG Binding Protein 2 Antibodies (MECP2)
On www.antibodies-online.com are 224 Methyl CpG Binding Protein 2 (MECP2) Antibodies from 25 different suppliers available. Additionally we are shipping Methyl CpG Binding Protein 2 Kits (13) and Methyl CpG Binding Protein 2 Proteins (13) and many more products for this protein. A total of 263 Methyl CpG Binding Protein 2 products are currently listed.
Synonyms:
1500041B07Rik, AUTSX3, BB130002, D630021H01Rik, Mbd5, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10
list all antibodies Gene Name GeneID UniProt
MECP2 29386 Q00566
MECP2 17257 Q9Z2D6
MECP2 4204 P51608

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Most Popular Reactivities for anti-Methyl CpG Binding Protein 2 (MECP2) Antibodies

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Top referenced anti-Methyl CpG Binding Protein 2 Antibodies

  1. Human Polyclonal MECP2 Primary Antibody for EIA, WB - ABIN357797 : dos Santos, Abdalla, Campos, Santos-Rebouças, Pimentel: The A140V mutation in the MECP2 gene is not a common etiological factor among Brazilian mentally retarded males. in Neuroscience letters 2005 (PubMed)
    Show all 4 references for 357797

  2. Human Polyclonal MECP2 Primary Antibody for ICC, IF - ABIN269308 : LaSalle, Goldstine, Balmer, Greco: Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometry. in Human molecular genetics 2001 (PubMed)
    Show all 4 references for 269308

  3. Human Polyclonal MECP2 Primary Antibody for EIA, FACS - ABIN953366 : Shapiro, Bibat, Hiremath, Blue, Hundalani, Yablonski, Kantipuly, Rohde, Johnston, Naidu: Bone mass in Rett syndrome: association with clinical parameters and MECP2 mutations. in Pediatric research 2010 (PubMed)
    Show all 3 references for 953366

  4. Cow (Bovine) Polyclonal MECP2 Primary Antibody for WB - ABIN2781332 : Robertson, Hall, Jacoby, Ellaway, de Klerk, Leonard: The association between behavior and genotype in Rett syndrome using the Australian Rett Syndrome Database. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006 (PubMed)
    Show all 2 references for 2781332

  5. Human Polyclonal MECP2 Primary Antibody for WB - ABIN389123 : Fang, Cheng, Chen, Lu, Yang, Zhu, Lu: Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. in World journal of gastroenterology : WJG 2004 (PubMed)

  6. Human Polyclonal MECP2 Primary Antibody for EIA - ABIN358521 : Tao, Hu, Chang, Wu, Sherman, Martinowich, Klose, Schanen, Jaenisch, Wang, Sun: Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)

More Antibodies against Methyl CpG Binding Protein 2 Interaction Partners

Mouse (Murine) Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. Loss of Mecp2 is associated with Rett syndrome.

  2. Mice that lacked Mecp2 in macrophages displayed spontaneous obesity, which was linked to impaired function of brown adipose tissue (BAT (show BAAT Antibodies)). Specifically, mutagenesis of a BAT (show BAAT Antibodies)-resident Cx3Cr1 (show CX3CR1 Antibodies)+ macrophage subpopulation compromised homeostatic thermogenesis but not acute, cold-induced thermogenesis. This was associated with diminished sympathetic innervation and local titers of norepinephrine.

  3. that histone deacetylase 3 (show HDAC3 Antibodies) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Antibodies) deacetylation, and disruption of HDAC3 (show HDAC3 Antibodies) contributes to cognitive and social impairment

  4. provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Antibodies)-associated protein 3 (show HSPB3 Antibodies) and establish the essential role of striatal Hdac1 (show HDAC1 Antibodies), Hdac2 (show HDAC2 Antibodies) and MeCP2 for suppression of repetitive behaviors

  5. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  6. MeCP2 dysfunction in excitatory neurons mediated elevated synchrony at baseline, while MeCP2 dysfunction in inhibitory neurons increased susceptibility to hypersynchronization in response to perturbations.

  7. Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in a mouse model of Rett syndrome.

  8. MeCP2 expression in the medullary respiratory network is sufficient for normal respiratory rhythm and preventing apnea. MeCP2 expression in the HoxA4 (show HOXA4 Antibodies) domain alone is critical for survival.

  9. Mecp2 is responsive to neuronal stimulation and IGF1 (show IGF1 Antibodies), and different stimuli have different effects on Mecp2 expression; this differential response may have downstream effects on functional mechanisms regulating brain development and plasticity.

  10. MeCP2 binding to chromosomal DNA in mouse brain is proportional to mCAC (show SLC25A20 Antibodies) + mCG density.

Human Methyl CpG Binding Protein 2 (MECP2) interaction partners

  1. MECP2 was increased at both mRNA and protein levels in gastric cancer (GC) compared with paracancerous tissues; MECP2 positive expression was correlated with the TNM (show ODZ1 Antibodies) stages, histological types, and lymph node metastasis status, but not with sex or age; dysregulated expression of MECP2 in GC and its correlation to clinicopathological parameters indicate that MECP2 may regulate the development of GC

  2. that histone deacetylase 3 (show HDAC3 Antibodies) interaction with MeCP2 positively regulates a subset of neuronal genes through FOXO (show FOXO3 Antibodies) deacetylation, and disruption of HDAC3 (show HDAC3 Antibodies) contributes to cognitive and social impairment

  3. C- and N-terminal interactions are required for healthy function of MeCP2.

  4. These findings position MeCP2 as a novel component in metabolic homeostasis. We previously showed that treatment of Mecp2 mice with statin drugs alleviated motor symptoms and improved health and longevity. Lipid metabolism is a highly treatable target; therefore, our results shed light on new metabolic pathways for treatment of Rett syndrome

  5. Based on these findings, the authors suggest that MeCP2 recognition of methylated/hydroxymethylated CpA (show CPA1 Antibodies) dinucleotides functions as an epigenetic switch redistributing MeCP2 among mCG and mCA (show RSPH1 Antibodies) loci.

  6. Following the recent demonstration of phenotype reversal in a mouse model of MECP2 Duplication, a clear understanding of the natural history is crucial to the design and implementation of future therapeutic strategies.

  7. we could not find any significant correlation between specific MECP2 mutations and individual clinical features or global clinical score in Rett syndrome patients

  8. findings demonstrate clear phenotype differences between FOXG1 (show FOXG1 Antibodies) and MECP2 disorders.

  9. Binding cooperativity makes MeCP2 an effective competitor with histone H1 (show H1F0 Antibodies) for accessible DNA sites. The relationship between MeCP2 binding specificity and cooperativity is discussed in the context of chromatin binding, neuronal function, and neuronal development.

  10. Our data indicate that these motifs are secondary contributors to DNA binding by MeCP2, and this view is supported by the absence of disease-causing missense mutations at these sites

Methyl CpG Binding Protein 2 (MECP2) Antigen Profile

Antigen Summary

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with Methyl CpG Binding Protein 2 (MECP2)

  • methyl CpG binding protein 2 (Mecp2) antibody
  • methyl CpG binding protein 2 (Rett syndrome) (MECP2) antibody
  • 1500041B07Rik antibody
  • AUTSX3 antibody
  • BB130002 antibody
  • D630021H01Rik antibody
  • Mbd5 antibody
  • MRX16 antibody
  • MRX79 antibody
  • MRXS13 antibody
  • MRXSL antibody
  • PPMX antibody
  • RS antibody
  • RTS antibody
  • RTT antibody
  • WBP10 antibody

Protein level used designations for MECP2

meCP-2 protein , methyl-CpG-binding protein 2 , meCp-2 protein

GENE ID SPECIES
29386 Rattus norvegicus
17257 Mus musculus
4204 Homo sapiens
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