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|Application / Reactivity||Human|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||7 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||14 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||24 Antibodies|
|Immunohistochemistry (IHC)||11 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Western Blotting (WB)||47 Antibodies|
|Antigen||Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies|
|Epitope||AA 1-620 Alternatives|
|Conjugate||This JAK3 antibody is un-conjugated Alternatives|
|5 references available|
|Supplier||Log in to see|
Product Details anti-JAK3 AntibodyTarget Details JAK3 Application Details Handling References for anti-JAK3 Antibody (ABIN393714) Images
|Specificity||JAK3 (AAH28068, 1 a.a. ~ 620 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||JAK3 (AAH28068, 1 a.a. ~ 620 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details JAK3Product Details anti-JAK3 Antibody Application Details Handling References for anti-JAK3 Antibody (ABIN393714) Images back to top
|Alternative Name||JAK3 (JAK3 Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||125099 DA|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure|
|Pathways||JAK-STAT Signaling, RTK Signaling|
Application DetailsProduct Details anti-JAK3 Antibody Target Details JAK3 Handling References for anti-JAK3 Antibody (ABIN393714) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml|
Background: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
|Restrictions||For Research Use only|
HandlingProduct Details anti-JAK3 Antibody Target Details JAK3 Application Details References for anti-JAK3 Antibody (ABIN393714) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-JAK3 Antibody (ABIN393714)Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling Images back to top
Kameda, Shide, Shimoda et al.: "Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma." in: International journal of hematology, Vol. 92, Issue 2, pp. 320-5, 2010 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
Lotz, Knutsen: "Janus kinase 3 missense mutation in a child with Jacobsen syndrome." in: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Vol. 104, Issue 6, pp. 536-7, 2010 (PubMed).
Chrencik, Patny, Leung et al.: "Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6." in: Journal of molecular biology, Vol. 400, Issue 3, pp. 413-33, 2010 (PubMed).
Han, Lan, Park et al.: "Polymorphisms in innate immunity genes and risk of childhood leukemia." in: Human immunology, Vol. 71, Issue 7, pp. 727-30, 2010 (PubMed).
ImagesProduct Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling References for anti-JAK3 Antibody (ABIN393714) back to top