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anti-Human JAK3 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended JAK3 Antibody (supplied by: Log in to see )

Antigen
Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
  • fae
  • JAK
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • RATJAK3
  • wil
Epitope
AA 610-660
15
15
13
12
11
8
7
7
5
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
79
55
39
2
2
2
2
1
1
1
Host
Rabbit
61
22
Clonality
Polyclonal
Conjugate
This JAK3 antibody is un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
36
22
13
10
9
7
5
2
1
1
1
1
Supplier
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Catalog No. ABIN681013
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008812695 ABIN742883 IF (p) IHC (p) WB Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN880421 IF (p) Alexa Fluor 555 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN880418 IF (p) Alexa Fluor 488 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN880422 IF (p) Alexa Fluor 350 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN880419 IF (p) Alexa Fluor 647 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN742886 IF (p) Cy3 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN742890 IF (p) FITC Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN742889 IF (p) Cy7 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN742887 IF (p) Cy5 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN742888 IF (p) Cy5.5 Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.0008812695 ABIN2803453 IF (p) Alexa Fluor 594 Rabbit IgG AA 971-990, pTyr980, pTyr981 Log in to see Polyclonal
0.0008812695 ABIN903223 IF (p) Alexa Fluor 350 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN903226 IF (p) Alexa Fluor 555 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN903227 IF (p) Alexa Fluor 647 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN903224 IF (p) Alexa Fluor 488 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN681017 IF (p) Cy5 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN681018 IF (p) Cy5.5 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN681020 IF (p) FITC Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN681016 IF (p) Cy3 Rabbit IgG AA 610-660 Log in to see Polyclonal
0.0008812695 ABIN681019 IF (p) Cy7 Rabbit IgG AA 610-660 Log in to see Polyclonal

Similar anti-JAK3 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 9 Antibodies 14 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 5 Antibodies
Immunofluorescence (IF) 6 Antibodies 12 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 9 Antibodies 11 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies 10 Antibodies
Western Blotting (WB) 21 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunoprecipitation (IP) 1 Antibodies

General

Antigen Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
Epitope AA 610-660
(15), (15), (13), (12), (11), (8), (7), (7), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(79), (55), (39), (2), (2), (2), (2), (1), (1), (1)
Host Rabbit
(61), (22)
Clonality
Polyclonal
Conjugate This JAK3 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(47), (36), (22), (13), (10), (9), (7), (5), (2), (1), (1), (1), (1)
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Product Details anti-JAK3 Antibody

Target Details JAK3 Application Details Handling Images
Specificity This has 85 % sequence similarity with JAK1 and may cross-react.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Jak3
Isotype IgG

Target Details JAK3

Product Details anti-JAK3 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Jak3 (JAK3 Antibody Abstract)
Background

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 Molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

Subcellular location: Cytoplasm


Synonyms: JAKL, LJAK, JAK-3, L-JAK, JAK3_HUMAN, Tyrosine-protein kinase JAK3, Janus kinase 3, Leukocyte janus kinase, JAK3
Gene ID 3718
UniProt P52333
Pathways JAK-STAT Signaling, RTK Signaling

Application Details

Product Details anti-JAK3 Antibody Target Details JAK3 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (AA 610-660) (ABIN681013) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Ja...
Immunohistochemistry (IHC) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (AA 610-660) (ABIN681013) Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Jak3 Polyclo...