anti-Mouse (Murine) MAP2K6 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended MAP2K6 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Antibodies
  • MAPKK6
  • MEK6
  • MKK6
  • PRKMK6
  • SAPKK-3
  • SAPKK3
  • Mkk6
  • Prkmk6
  • ANQ1
  • ARABIDOPSIS NQK1
  • ARABIDOPSIS THALIANA MAP KINASE KINASE 6
  • ATMKK6
  • MAP kinase kinase 6
  • MIK19.2
  • MIK19_2
  • MKK3
  • map2k3
  • zMKK3
  • mitogen-activated protein kinase kinase 6
  • MAP2K6
  • Map2k6
  • MKK6
  • map2k6
Reactivity
Human, Mouse (Murine), Rat (Rattus)
195
130
97
5
4
4
2
2
1
1
1
1
1
1
1
Host
Rabbit
172
44
2
Clonality
Polyclonal
Conjugate
This MAP2K6 antibody is un-conjugated
5
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
180
78
75
44
37
26
16
15
11
7
3
2
1
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Catalog No. ABIN681568
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN743903 IF (p) IHC (p) WB Rabbit IgG pSer202 Log in to see Polyclonal
1 ABIN2804135 IF (p) Alexa Fluor 594 Rabbit IgG Log in to see Polyclonal
1 ABIN2804136 IF (p) Alexa Fluor 594 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN681571 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
1 ABIN681572 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
1 ABIN681573 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
1 ABIN681574 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
1 ABIN681575 IF (p) FITC Rabbit IgG Log in to see Polyclonal
1 ABIN743891 IF (p) Cy3 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN743892 IF (p) Cy5 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN743893 IF (p) Cy5.5 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN743894 IF (p) Cy7 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN743895 IF (p) FITC Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN874786 IF (p) Alexa Fluor 488 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN874787 IF (p) Alexa Fluor 555 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN874788 IF (p) Alexa Fluor 647 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN874790 IF (p) Alexa Fluor 350 Rabbit IgG pSer207 Log in to see Polyclonal
1 ABIN906112 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
1 ABIN906113 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
1 ABIN906115 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal

General

Antigen Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(195), (130), (97), (5), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(172), (44), (2)
Clonality
Polyclonal
Conjugate This MAP2K6 antibody is un-conjugated
(5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(180), (78), (75), (44), (37), (26), (16), (15), (11), (7), (3), (2), (1)
Pubmed 1 reference available
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Product Details anti-MAP2K6 Antibody

Target Details MAP2K6 Application Details Handling References for anti-MAP2K6 antibody (ABIN681568) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human MEK6
Isotype IgG

Target Details MAP2K6

Product Details anti-MAP2K6 Antibody Application Details Handling References for anti-MAP2K6 antibody (ABIN681568) Images back to top
Antigen
Alternative Name Mek6 (MAP2K6 Antibody Abstract)
Background

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Subcellular location: Cytoplasm, Nucleus

Synonyms: MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3, Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, MAP2K6, SKK3

Gene ID 5608
UniProt P52564
Research Area Immunology, Innate Immunity, Tyrosine Kinases, Kinases/Phosphatases
Pathways MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades

Application Details

Product Details anti-MAP2K6 Antibody Target Details MAP2K6 Handling References for anti-MAP2K6 antibody (ABIN681568) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-MAP2K6 Antibody Target Details MAP2K6 Application Details References for anti-MAP2K6 antibody (ABIN681568) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-MAP2K6 antibody (ABIN681568)

Product Details anti-MAP2K6 Antibody Target Details MAP2K6 Application Details Handling Images back to top
Product cited in:

Shi, Zhan, Zhao, Wang, Ma: "Effects of Fluoride on the Expression of p38MAPK Signaling Pathway-Related Genes and Proteins in Spleen Lymphocytes of Mice." in: Biological trace element research, Vol. 173, Issue 2, pp. 333-8, 2016