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Browse our anti-MAP3K11 (MAP3K11) Antibodies

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 11 Antibodies (MAP3K11)
On www.antibodies-online.com are 59 Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) Antibodies from 16 different suppliers available. Additionally we are shipping MAP3K11 Proteins (5) and many more products for this protein. A total of 68 MAP3K11 products are currently listed.
Synonyms:
2610017K16Rik, MEKK11, Mlk-3, Mlk3, PTK1, RHOE, SPRK
list all antibodies Gene Name GeneID UniProt
MAP3K11 4296 Q16584
MAP3K11 26403 Q80XI6
MAP3K11 309168 Q66HA1

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Most Popular Reactivities for anti-MAP3K11 (MAP3K11) Antibodies

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anti-Human MAP3K11 Antibodies:

anti-Mouse (Murine) MAP3K11 Antibodies:

anti-Rat (Rattus) MAP3K11 Antibodies:

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Top referenced anti-MAP3K11 Antibodies

  1. Human Monoclonal MAP3K11 Primary Antibody for WB - ABIN659128 : Chen, Miller, Gallo: MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells. in Oncogene 2010 (PubMed)
    Show all 3 references for ABIN659128

  2. Human Polyclonal MAP3K11 Primary Antibody for WB - ABIN651367 : Rangasamy, Mishra, Mehrotra, Sondarva, Ray, Rao, Chatterjee, Rana, Rana: Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells. in Cancer research 2010 (PubMed)
    Show all 3 references for ABIN651367

  3. Human Polyclonal MAP3K11 Primary Antibody for IHC, ELISA - ABIN1533179 : Ing, Leung, Heng, Tsui, Lassam: MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. in Oncogene 1994 (PubMed)

  4. Cow (Bovine) Polyclonal MAP3K11 Primary Antibody for WB - ABIN2786655 : Muniyappa, Das: Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism. in Cellular signalling 2008 (PubMed)

More Antibodies against MAP3K11 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) interaction partners

  1. During hepatocyte lipotoxicity, activated MLK3 induces the release of CXCL10 (show CXCL10 Antibodies)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.

  2. MLK3 serves as a common upstream kinase of AMPK (show PRKAA1 Antibodies) and JNK (show MAPK8 Antibodies) and functions as a direct upstream kinase for AMPK (show PRKAA1 Antibodies) independent of LKB1 (show STK11 Antibodies)

  3. MLK3 represents a newly recognized integral component of HER2 (show ERBB2 Antibodies) biology in HER2 (show ERBB2 Antibodies)+ breast tumors.

  4. MLK3 is a critical factor controlling the activity of kinase networks that control the cellular responses to different concentrations of reactive oxygen species.

  5. Signaling pathways associated with the Pro252His mutation in MLK3 are located in the kinase domain which is an important domain for the regulation of downstream signaling pathways.

  6. CHIP modulates MLK3 protein levels in response to Geldanamycin and stress stimuli, and CHIP-dependent regulation of MLK3 is required for suppression of SKOV3 ovarian cancer cell invasion.

  7. Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.

  8. CTGF acting through Rac1 activates the MLK3/JNK signaling pathway, which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately induces collagen I expression in human lung fibroblasts

  9. NS5A targets MLK3 with multiple downstream consequences for both apoptosis and K(+) homeostasis.

  10. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (show MAPK8IP1 Antibodies) scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11) interaction partners

  1. MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia.

  2. During hepatocyte lipotoxicity, activated MLK3 (show KCNK7 Antibodies) induces the release of CXCL10 (show CXCL10 Antibodies)-bearing vesicles from hepatocytes, which are chemotactic for macrophages.

  3. TRB3 (show TRIB3 Antibodies)(-/-) islets show a decrease in both the amplitude and duration of cytokine-stimulated MLK3 (show KCNK7 Antibodies) induction and JNK (show MAPK8 Antibodies) activation.

  4. MLK3 (show KCNK7 Antibodies) limits RhoA (show RHOA Antibodies) activation and injury-induced neointima formation by binding to and inhibiting the activation of p63Rho guanine nucleotide exchange factor (show ARHGEF12 Antibodies), a RhoA (show RHOA Antibodies) activator.

  5. Genetic or pharmacologic inhibition of MLK3 (show KCNK7 Antibodies) blocks fMLP (show FPR1 Antibodies)-mediated motility of neutrophils both in vitro and in vivo, suggesting that MLK3 (show KCNK7 Antibodies) may be a therapeutic target in human diseases characterized by exuberant neutrophil migration.

  6. Data indicate URMC-099 as an orally bioavailable, potent mixed lineage kinase 3 MLK3 inhibitor.

  7. Data from knockout mice suggest that MLK3 (show KCNK7 Antibodies) plays role in saturated fatty acid-induced activation of MAP kinase (show MAPK1 Antibodies) signaling; MLK3 (show KCNK7 Antibodies) appears to be involved in pathogenesis of obesity, adipose tissue in fl ammation, insulin (show INS Antibodies) resistance, and fatty liver disease.

  8. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 (show MAPK8IP1 Antibodies) scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death

  9. These results reveal a novel role for MLK3 (show KCNK7 Antibodies) signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 (show KCNK7 Antibodies) may be an important target for the regulation of intestinal mucosal healing.

  10. mice with a targeted deletion of Mlk3 (show KCNK7 Antibodies) displayed multiple skeletal defects, including dental abnormalities, deficient calvarial mineralization, and reduced bone mass

MAP3K11 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

Alternative names and synonyms associated with MAP3K11

  • mitogen-activated protein kinase kinase kinase 11 (MAP3K11) antibody
  • mitogen-activated protein kinase kinase kinase 11 (Map3k11) antibody
  • 2610017K16Rik antibody
  • MEKK11 antibody
  • Mlk-3 antibody
  • Mlk3 antibody
  • PTK1 antibody
  • RHOE antibody
  • SPRK antibody

Protein level used designations for MAP3K11

SH3 domain-containing proline-rich kinase , mixed lineage kinase 3 , protein-tyrosine kinase PTK1 , src-homology 3 domain-containing proline-rich kinase , mitogen activated protein kinase kinase kinase 11

GENE ID SPECIES
4296 Homo sapiens
26403 Mus musculus
309168 Rattus norvegicus
483732 Canis lupus familiaris
514210 Bos taurus
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