Browse our anti-Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antibodies

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anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antibodies (PKD1)
On www.antibodies-online.com are 58 Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antibodies from 11 different suppliers available. Additionally we are shipping Polycystic Kidney Disease 1 (Autosomal Dominant) Kits (6) and Polycystic Kidney Disease 1 (Autosomal Dominant) Proteins (4) and many more products for this protein. A total of 70 Polycystic Kidney Disease 1 (Autosomal Dominant) products are currently listed.
Synonyms:
mFLJ00285, PBP, Pc-1, PC1, Pkcm, PKD, PKD1, Prkcm, TRPP1
list all antibodies Gene Name GeneID UniProt
PKD1 5310 P98161
PKD1 18763 O08852
PKD1 24650  

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Top referenced anti-Polycystic Kidney Disease 1 (Autosomal Dominant) Antibodies

  1. Human Polyclonal PKD1 Primary Antibody for IF (p), IHC (p) - ABIN678083 : Chiou, Sang, Cheng, Ho, Wang, Pan: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. in Carcinogenesis 2013 (PubMed)
    Show all 3 references for 678083

More Antibodies against Polycystic Kidney Disease 1 (Autosomal Dominant) Interaction Partners

Human Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. A novel mutation of the PKD1 gene has been identified with autosomal dominant polycystic kidney disease in an affected Chinese family.

  2. Annualized median liver growth rates were 1.68, 1.5 and 1.24% for PKD1-T, PKD1-NT and PKD2 (show PKD2 Antibodies) mutations, respectively (P = 0.49), and remained unaffected by the ADPKD genotype when adjusted for age, gender and baseline HtLV.

  3. this study shows that diet-induced obesity links to estrogen receptor (show ESR1 Antibodies)-positive breast cancer progression via LPA (show APOA Antibodies)/PKD-1-CD36 (show CD36 Antibodies) signaling-mediated microvascular remodeling

  4. Isolated polycystic liver disease genes define effectors of polycystin-1 function

  5. mechanical load upregulates expression of Runx2 (show RUNX2 Antibodies) gene via potentiation of PC1 (show PCSK1 Antibodies)-JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.

  6. Gly972Arg of PC-1 (show PCSK1 Antibodies) polymorphisms are associated with polycystic ovary syndrome.

  7. cortactin (show CTTN Antibodies) binds to E-cadherin (show CDH1 Antibodies), and that a posttranslational modification of cortactin (show CTTN Antibodies), RhoA (show RHOA Antibodies)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (show PRKD1 Antibodies)) at S298, impairs adherens junction assembly and supports their dissolution.

  8. Ten novel mutations in PKD1 gene were identified in 15 Chinese families with polycystic kidney disease.

  9. PKD1 mutations are associated with autosomal dominant polycystic kidney disease.

  10. The novel PKD1 c.8791+1_8791+5delGTGCG mutation has created a new splice site.

Mouse (Murine) Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) interaction partners

  1. critical functions of PC1 (show PCSK1 Antibodies) are regulated by its ability to sense cytosolic calcium levels via binding to calmodulin (show Calm2 Antibodies)

  2. cortactin (show CTTN Antibodies) binds to E-cadherin (show CDH1 Antibodies), and that a posttranslational modification of cortactin (show CTTN Antibodies), RhoA (show RHOA Antibodies)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (show PRKD1 Antibodies)) at S298, impairs adherens junction assembly and supports their dissolution.

  3. Galpha12 (show GNA12 Antibodies) is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.

  4. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.

  5. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7 (show HDAC7 Antibodies), where it interacts with forkhead box protein O1 (show FOXO1 Antibodies) to suppress endothelial CD36 (show CD36 Antibodies) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  6. kd1 mutant mice have transcriptional profiles consistent with changes in lipid metabolism and distinct metabolite and complex lipid profiles in kidneys. .. cells lacking Pkd1 have an intrinsic fatty acid oxidation defect and that manipulation of lipid content of mouse chow modifies cystic disease.

  7. Polycystin 1 was overexpressed in M1 cells, no increase in any of these parameters was detected

  8. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.

  9. detected a marked increase in the localization of beta-catenin (show CTNNB1 Antibodies) in the nucleus of crypt epithelial cells in the ileum of PKD1

  10. PKD1 phosphorylates AMPKalpha2 (show PRKAA2 Antibodies) at Ser485/491, thus diminishing AMPK (show PRKAA1 Antibodies) activity.

Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1) Antigen Profile

Antigen Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Alternative names and synonyms associated with Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1)

  • polycystic kidney disease 1 (autosomal dominant) (PKD1) antibody
  • polycystic kidney disease 1 homolog (Pkd1) antibody
  • polycystic kidney disease 1 homolog (human) (Pkd1) antibody
  • protein kinase D1 (Prkd1) antibody
  • mFLJ00285 antibody
  • PBP antibody
  • Pc-1 antibody
  • PC1 antibody
  • Pkcm antibody
  • PKD antibody
  • PKD1 antibody
  • Prkcm antibody
  • TRPP1 antibody

Protein level used designations for PKD1

polycystic kidney disease 1 (autosomal dominant) , polycystin 1 , autosomal dominant polycystic kidney disease 1 protein , polycystic kidney disease-associated protein , polycystin-1 , transient receptor potential cation channel, subfamily P, member 1 , polycystic kidney disease protein 1 , autosomal dominant polycystic kidney disease 1 protein homolog , polycystic kidney disease 1 homolog; polycystin-1 , nPKC-D1 , nPKC-mu , protein kinase C mu type , protein kinase C, mu , protein kinase D , serine/threonine-protein kinase D1

GENE ID SPECIES
416553 Gallus gallus
749291 Pan troglodytes
5310 Homo sapiens
606755 Canis lupus familiaris
100516429 Sus scrofa
18763 Mus musculus
24650 Rattus norvegicus
18760 Mus musculus
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