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|Antigen||Interleukin 1 Receptor, Type I (IL1R1) Antibodies|
|Epitope||AA 1-352 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This IL1R1 antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|1 reference available|
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Product Details anti-IL1R1 AntibodyTarget Details IL1R1 Application Details Handling References for anti-IL1R1 antibody (ABIN2001603) Images
|Specificity||Rat IL-1R1 / CD121a|
|Characteristics||Produced in rabbits immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a, ABIN2009064 NP_037255.3, Met 1-Lys 352,. IL-1R1 / CD121a specific IgG was purified by Rat IL-1R1 / CD121a affinity chromatography.|
|Purification||purified by affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat IL-1R1 / CD121a protein (ABIN2009064)|
Target Details IL1R1Product Details anti-IL1R1 Antibody Application Details Handling References for anti-IL1R1 antibody (ABIN2001603) Images back to top
|Alternative Name||IL1R1 (IL1R1 Antibody Abstract)|
|Background||Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.|
|Pathways||NF-kappaB Signaling, Carbohydrate Homeostasis|
Application DetailsProduct Details anti-IL1R1 Antibody Target Details IL1R1 Handling References for anti-IL1R1 antibody (ABIN2001603) Images back to top
WB: 5-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat IL1R1. The detection limit for Rat IL1R1 is approximately 0.00975 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL1R1 Antibody Target Details IL1R1 Application Details References for anti-IL1R1 antibody (ABIN2001603) Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
References for anti-IL1R1 antibody (ABIN2001603)Product Details anti-IL1R1 Antibody Target Details IL1R1 Application Details Handling Images back to top
Vigers, Anderson, Caffes, Brandhuber: "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta." in: Nature, Vol. 386, Issue 6621, pp. 190-4, 1997
ImagesProduct Details anti-IL1R1 Antibody Target Details IL1R1 Application Details Handling References for anti-IL1R1 antibody (ABIN2001603) back to top