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Browse our TNFRSF1A Proteins (TNFRSF1A)

Full name:
Tumor Necrosis Factor Receptor Superfamily, Member 1A Proteins (TNFRSF1A)
On www.antibodies-online.com are 65 Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Proteins from 17 different suppliers available. Additionally we are shipping TNFRSF1A Antibodies (446) and TNFRSF1A Kits (60) and many more products for this protein. A total of 596 TNFRSF1A products are currently listed.
Synonyms:
CD120a, FPF, MS5, p55, p55-R, p60, TBP1, TNF-alphaR1, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNFalpha-R1, TNFAR, Tnfr-2, Tnfr1, TNFR1-d2, TNFR55, TNFR60, TNFR I, TNFRI, TNFRp55, TNFRSF1A, wu:fj65b10, xtnfr1, zgc:85914
list all proteins Gene Name GeneID UniProt
TNFRSF1A 7132 P19438
TNFRSF1A 21937 P25118
TNFRSF1A 25625 P22934

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TNFRSF1A Proteins (TNFRSF1A) by Origin

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Top referenced TNFRSF1A Proteins

  1. Human TNFRSF1A Protein expressed in Escherichia coli (E. coli) - ABIN1047844 : Gray, Barrett, Chantry, Turner, Feldmann: Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 5 references for ABIN1047844

  2. Mouse (Murine) TNFRSF1A Protein expressed in Human Cells - ABIN2007897 : Banner, DArcy, Janes, Gentz, Schoenfeld, Broger, Loetscher, Lesslauer: Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. in Cell 1993 (PubMed)
    Show all 5 references for ABIN2007897

  3. Rat (Rattus) TNFRSF1A Protein expressed in Human Cells - ABIN2009259 : Chan, Chun, Zheng, Siegel, Bui, Lenardo: A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. in Science (New York, N.Y.) 2000 (PubMed)
    Show all 5 references for ABIN2009259

  4. Human TNFRSF1A Protein expressed in Human Cells - ABIN2003513 : Lewis, Tartaglia, Lee, Bennett, Rice, Wong, Chen, Goeddel: Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 5 references for ABIN2003513

  5. Human TNFRSF1A Protein expressed in HEK-293 Cells - ABIN2181837 : Jiang, Woronicz, Liu, Goeddel: Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 references for ABIN2181837

  6. Human TNFRSF1A Protein expressed in Escherichia coli (E. coli) - ABIN1098686 : Dunbar, Song, Guo, Wu, Donner: Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 2 references for ABIN1098686

More Proteins for TNFRSF1A Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Voxel-based morphometry was used to analyse the associations between TNFRSF1A (rs4149576 and rs4149577) and grey matter structure. Highly significant genotypic associations with striatal volume but not the hippocampus were seen. Specifically, for rs4149576, G homozygotes were associated with reduced caudate nucleus volumes relative to A homozygotes and heterozygotes. Reduced caudate volumes were observed in C homozygotes

  2. Circulating TNFR1 and 2 were shown to be associated with cardiovascular disease, independent of age, sex, inflammatory markers, and other cardiovascular disease risk factors, in the chronic kidney disease patients

  3. Infection with C. trachomatis disturbs TNFR1 signalling specifically at the level of receptor internalization.

  4. Data suggest that TRAF2 (TNF receptor-associated factor 2 (show TRAF2 Proteins)) negatively regulates (1) TNFR1- (tumor necrosis factor binding protein 1)-induced apoptosis, (2) TNFR2 (show TNFRSF1B Proteins)- (tumor necrosis factor (show TNF Proteins) receptor type 2)-induced non-canonical NFkappaB (show NFKB1 Proteins) signaling, and (3) TNF- (tumor necrosis factor (show TNF Proteins))-induced necroptosis. [REVIEW]

  5. Our analysis showed that the TNFR1 rs2234649 polymorphism does not increase ankylosing spondylitis risk. In conclusion, the TNFR1 gene polymorphism tested does not appear to be useful for assessing predisposition to ankylosing spondylitis.

  6. The data demonstrate a novel and unexpected function of BIG1 that regulates TNFR1 signaling by targeting TRAF2 (show TRAF2 Proteins).

  7. Data indicate that plasma concentrations of TNFR1 and TNFR2 (show TNFRSF1B Proteins) are elevated in pediatric lupus nephritis.

  8. TNFR1 is the major pro-inflammatory mediator of TNF-alpha in fibroblast-like synoviocytes (FLS), whereas TNFR2, may act as an immunosuppressor in FLS for the prevention of overwhelming inflammatory reactions.

  9. These results strongly indicate that anti-inflammatory effects in TNF-alpha (show TNF Proteins)-stimulated endothelial cells by acetylation are tightly linked to secreted APE1/Ref-1 (show APEX1 Proteins), which inhibits TNF-alpha (show TNF Proteins) binding to TNFR1 by reductive conformational change, with suggestion as an endogenous inhibitor of vascular inflammation.

  10. Results suggest that miR (show MLXIP Proteins)-29a is an important regulator of tumor necrosis factor receptor 1 expression in breast cancer and functions as a tumor suppressor by targeting tumor necrosis factor receptor 1 to influence the growth of MCF-7 cell.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Results suggest that elevated TNF (show TNF Proteins) in the heart, via TNFR1 and TNFR2 (show TNFRSF1B Proteins), restrains cardiomyocyte differentiation of resident cardiac stem cells and may enhance adrenergic activation, both effects that would reduce the effectiveness of endogenous cardiac repair and the response to exogenous stem cell therapy, while promoting adverse cardiac remodeling.

  2. Suggest an atheroprotective role of ADAM17 (show ADAM17 Proteins), which might be mediated by cleaving membrane-bound TNFalpha (show TNF Proteins) and TNFR2 (show TNFRSF1B Proteins), thereby preventing overactivation of endogenous TNFR2 (show TNFRSF1B Proteins) signaling in cells of the vasculature.

  3. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha (show TNF Proteins). This induction coincides with ensheathment of these axons by associated glia via a TNF (show TNF Proteins) receptor 2 (TNFR2 (show TNFRSF1B Proteins))-mediated process.

  4. this study shows that Tnfr1 knock-out display reduced chemotaxis of myeloid-derived suppressor cells to tumor, and mice reject transplanted tumor

  5. tumor necrosis factor-alpha (show TNF Proteins), through its receptor tumor necrosis factor receptor -1, promoted cell proliferation and cell survival in prostate by activation of the AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) and NFKB pathway, which stimulated prostate carcinogenesis

  6. Report chronic inflammatory multiorgan hepatobiliary pancreatitis, along with fibrosis and calculi formation induced by oral dibutyltin administration in TNFR1/R2 deficient mice.

  7. Data, including data from studies in knockout mice, suggest that TNF (tumor necrosis factor (show TNF Proteins)), TNFR1 (TNF (show TNF Proteins) receptor 1), and IL18 (interleukin 18 (show IL18 Proteins)) are involved in liver lipid metabolism. IL18 (show IL18 Proteins) or TNFR1 knockout mice on chow show higher liver triglyceride deposition than wild-type mice fed chow; in IL18 (show IL18 Proteins) or TNFR1 knockout mice, high-refined-carbohydrate diet does not lead to fatty liver disease as it does in wild-type mice.

  8. Knockdown of TNFR1 not only inhibited the JNK (show MAPK8 Proteins) pathway but also reduced Toll-like receptor 2 protein and RANKL (show TNFSF11 Proteins) levels in S. aureus-infected cells.

  9. we have demonstrated that PGRN (show GRN Proteins)-mediated inhibition of chemokine (show CCL1 Proteins) expression largely depends on TNFR1.

  10. The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7 (show PGLYRP1 Proteins)-Hsp70 (show HSP70 Proteins) and the Tag 7 (show PGLYRP1 Proteins) component of this complex with TNFR1 receptor in solution and in tumor cells are presented.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Retinal ischemia results in increased expression of TNF-alpha (show TNF Proteins) and its receptors (TNF-R1 and TNF-R2 (show TNFRSF1B Proteins)).

Cow (Bovine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. These results suggest that TNF-alpha (show TNF Proteins) sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII (show TNFRSF1B Proteins) are present in the luteal cells of the bovine corpus luteum.

  2. The expression and cellular localization of tumor necrosis factor-alpha (TNF (show TNF Proteins)) and its receptors (TNFRI and TNFRII (show TNFRSF1B Proteins)) mRNAs and proteins, were determined.

  3. The upregulation of TNFRI mRNA expression by IFNG (show IFNG Proteins) suggests that TNF (show TNF Proteins) and IFNG (show IFNG Proteins) synergistically affect the death of luteal endothelial cells resulting in acute luteolysis

  4. TNF (show TNF Proteins) binding induces release of AIP1 (DAB2IP (show DAB2IP Proteins)) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD (show TRADD Proteins), RIP1 (show RALBP1 Proteins), TRAF2 (show TRAF2 Proteins), and AIPl.

Zebrafish Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Proteins) in zebrafish embryos results in the induction of a caspase-8 (show CASP8 Proteins), caspase-2 (show CASP2 Proteins) and P53 (show TP53 Proteins)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Proteins).

TNFRSF1A Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Alternative names and synonyms associated with TNFRSF1A

  • tumor necrosis factor receptor superfamily, member 1A (tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A)
  • tumor necrosis factor receptor superfamily, member 1a (Tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1A (Tnfrsf1a)
  • tumor necrosis factor receptor superfamily, member 1a (tnfrsf1a)
  • CD120a protein
  • FPF protein
  • MS5 protein
  • p55 protein
  • p55-R protein
  • p60 protein
  • TBP1 protein
  • TNF-alphaR1 protein
  • TNF-R protein
  • TNF-R-I protein
  • TNF-R1 protein
  • TNF-R55 protein
  • TNFalpha-R1 protein
  • TNFAR protein
  • Tnfr-2 protein
  • Tnfr1 protein
  • TNFR1-d2 protein
  • TNFR55 protein
  • TNFR60 protein
  • TNFR I protein
  • TNFRI protein
  • TNFRp55 protein
  • TNFRSF1A protein
  • wu:fj65b10 protein
  • xtnfr1 protein
  • zgc:85914 protein

Protein level used designations for TNFRSF1A

tumor necrosis factor receptor 1 , tumor necrosis factor receptor p60 , tumor necrosis factor receptor superfamily member 1A , tumor necrosis factor type I , tumor necrosis factor receptor superfamily, member 1A , tumor necrosis factor receptor superfamily member 1A-like , TNF-R1 , TNF-RI , TNFR-I , tumor necrosis factor binding protein 1 , tumor necrosis factor receptor 1A isoform beta , tumor necrosis factor receptor type 1 , tumor necrosis factor-alpha receptor , TNF receptor alpha chain , TNF-alpha-R1 , p60 , tumor necrosis factor receptor type I , p55 , p55 TNF receptor , TNF Receptor 1 (TR1) , TNFR1

GENE ID SPECIES
100137626 Xenopus laevis
100144930 Xenopus (Silurana) tropicalis
403634 Canis lupus familiaris
466934 Pan troglodytes
493957 Felis catus
722033 Macaca mulatta
100059548 Equus caballus
100135698 Ovis aries
100397418 Callithrix jacchus
7132 Homo sapiens
21937 Mus musculus
25625 Rattus norvegicus
397020 Sus scrofa
282527 Bos taurus
418325 Gallus gallus
100713890 Cavia porcellus
406471 Danio rerio
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