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High plasma levels of TNFR1 and TNFR2 (show TNFRSF1B Proteins) were associated with incident intracerebral hemorrhage.
Renal clear cell carcinoma cells cells express increased amounts of RIPK1 (show RIPK1 Proteins) and RIPK3 (show RIPK3 Proteins) and are poised to undergo necroptosis in response to TNFR1 signaling.
TRIM28 (show TRIM28 Proteins) acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 and -2 and VEGF receptor 2 in endothelial cells
Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1 (show UQCRFS1 Proteins), and IRAK1 (show IRAK1 Proteins), we hypothesize that SH exerts its NF-kappaB (show NFKB1 Proteins) activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 (show TLR3 Proteins) complexes in the plasma membrane of infected cells.
a specific link between the penetrance of the TNFRSF1A mutation and the observed T cell phenotype, is reported.
Collectively, this study provides more insights into RELT (show RELT Proteins) expression, RELT (show RELT Proteins) family member function, and the mechanism of RELT (show RELT Proteins)-induced death.
Burkholderia cenocepacia BcaA binds to tumor necrosis factor receptor 1.
In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression
TNFRSF1A variants were identified in 10 tumor necrosis factor (show TNF Proteins) receptor-associated periodic syndrome patients from 10 independent families. The T61I variant was found in patients, while the V136M and S321I variants were found in 1 patient each. All the patients were heterozygous for the variants. Among the healthy controls, 7 of 363 individuals were heterozygous for the T61I variant.
Voxel-based morphometry was used to analyse the associations between TNFRSF1A (rs4149576 and rs4149577) and grey matter structure. Highly significant genotypic associations with striatal volume but not the hippocampus were seen. Specifically, for rs4149576, G homozygotes were associated with reduced caudate nucleus volumes relative to A homozygotes and heterozygotes. Reduced caudate volumes were observed in C homozygotes
The deficiency of TNFRp55 promoted the development of endometriosis.
TNFalpha (show TNF Proteins) enhanced murine NK cell IFNgamma production via TNFR2 (show TNFRSF1B Proteins) in vitro
TNFR2 (show TNFRSF1B Proteins) sensitizes macrophages for endogenous TNF (show TNF Proteins)-induced TNFR1-mediated necroptosis
this study shows that epithelial TNFR1 signaling promotes mucosal repair in inflammatory bowel disease
HACE1 (show HACE1 Proteins) controls TNF (show TNF Proteins)-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1-RIP3 kinase-necroptosis pathway.
impaired TNF (show TNF Proteins)/TNFR2 (show TNFRSF1B Proteins) signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation.
TNFR2 (show TNFRSF1B Proteins) activation exerted beneficial effects on OPA1 expression in an aortic constriction model.
Following activation by transmembrane TNF (show TNF Proteins), TNFR2 (show TNFRSF1B Proteins) initiates pathways that drive oligodendrocytes into a reparative mode contributing to remyelination following disease
The apoptotic signals through TNFR1 appear critical for the pathogenesis of pulmonary emphysema.
Retinal ischemia results in increased expression of TNF-alpha (show TNF Proteins) and its receptors (TNF-R1 and TNF-R2 (show TNFRSF1B Proteins)).
These results suggest that TNF-alpha (show TNF Proteins) sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII (show TNFRSF1B Proteins) are present in the luteal cells of the bovine corpus luteum.
The expression and cellular localization of tumor necrosis factor-alpha (TNF (show TNF Proteins)) and its receptors (TNFRI and TNFRII (show TNFRSF1B Proteins)) mRNAs and proteins, were determined.
The upregulation of TNFRI mRNA expression by IFNG (show IFNG Proteins) suggests that TNF (show TNF Proteins) and IFNG (show IFNG Proteins) synergistically affect the death of luteal endothelial cells resulting in acute luteolysis
TNF (show TNF Proteins) binding induces release of AIP1 (DAB2IP (show DAB2IP Proteins)) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD (show TRADD Proteins), RIP1 (show RALBP1 Proteins), TRAF2 (show TRAF2 Proteins), and AIPl.
Targeted gene knockdown of TNFRSF1B (show TNFRSF1B Proteins) in zebrafish embryos results in the induction of a caspase-8 (show CASP8 Proteins), caspase-2 (show CASP2 Proteins) and P53 (show TP53 Proteins)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (show CASP3 Proteins).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
tumor necrosis factor receptor 1
, tumor necrosis factor receptor p60
, tumor necrosis factor receptor superfamily member 1A
, tumor necrosis factor type I
, tumor necrosis factor receptor superfamily, member 1A
, tumor necrosis factor receptor superfamily member 1A-like
, tumor necrosis factor binding protein 1
, tumor necrosis factor receptor 1A isoform beta
, tumor necrosis factor receptor type 1
, tumor necrosis factor-alpha receptor
, TNF receptor alpha chain
, tumor necrosis factor receptor type I
, p55 TNF receptor
, TNF Receptor 1 (TR1)